478647-31-3Relevant articles and documents
Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs
Young, Robert J.,Campbell, Matthew,Borthwick, Alan D.,Brown, David,Burns-Kurtis, Cynthia L.,Chan, Chuen,Convery, Maire A.,Crowe, Miriam C.,Dayal, Satish,Diallo, Hawa,Kelly, Henry A.,Paul King,Kleanthous, Savvas,Mason, Andrew M.,Mordaunt, Jackie E.,Patel, Champa,Pateman, Anthony J.,Senger, Stefan,Shah, Gita P.,Smith, Paul W.,Watson, Nigel S.,Weston, Helen E.,Zhou, Ping
, p. 5953 - 5957 (2006)
Structure-based drug design was exploited in the synthesis of 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group with acyclic tertiary amide termini. Optimized hydrophobic contacts
Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl} sulfonamides
Chan, Chuen,Borthwick, Alan D.,Brown, David,Burns-Kurtis, Cynthia L.,Campbell, Matthew,Chaudry, Laiq,Chung, Chun-Wa,Convery, Máire A.,Hamblin, J. Nicole,Johnstone, Lisa,Kelly, Henry A.,Kleanthous, Savvas,Patikis, Angela,Patel, Champa,Pateman, Anthony J.,Senger, Stefan,Shah, Gita P.,Toomey, John R.,Watson, Nigel S.,Weston, Helen E.,Whitworth, Caroline,Young, Robert J.,Zhou, Ping
, p. 1546 - 1557 (2008/02/01)
Factor Xa inhibitory activities for a series of N-{(3S)-1-[(1S)-1-methyl-2- morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides with different P1 groups are described. These data provide insight into binding interactions within the S1 primary spe
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(E)-2-(5-Chlorothien-2-yl)-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}ethenesulfonamide in substantially crystalline form, pharmaceutical formulations thereof, processes for preparing it, and its use inmedicine, particularl
