478849-84-2

Upstream product

• 33082-77-8 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)ethanoic acid 
• 354574-31-5 2-iodo-6-methoxybenzenamine 

Downstream Products

• 949115-25-7 tert-butyl (1,4-dioxaspiro[4.5]dec-7-en-8-ylacetyl)(2-iodo-6-methoxyphenyl)carbamate 
• 478849-86-4 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodophenyl)-N-methylacetamide 

Relevant academic research and scientific papers

Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization

Cyclizations of bicyclic amides via an intramolecular Heck reaction followed by an oxidation reaction generate tricyclic spirocyclohexadienones. From these compounds, tetracyclic ketones can be synthesized to provide useful intermediates for the synthesis

Total synthesis of galanthamine, analogues and derivatives thereof

The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form =0, R3,