478910-90-6

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 478910-89-3 2-(2-hydroxymethyl-5,6,4'-trimethoxy-biphenyl-3-yl)-ethanol 
• 85010-19-1 4,4-dimethyl-2-(2,3,4-trimethoxyphenyl)-4,5-oxazoline 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 478910-76-8 2-[2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-5,6,4'-trimethoxybiphenyl-3-yl]ethanol 
• 478910-77-9 6,7-dimethoxy-8-(4-methoxyphenyl)isochroman-1-one 
• 99425-57-7 2-<2-(4-methoxyphenyl)-3,4-dimethoxyphenyl>-4,4-dimethyl-2-oxazoline 

Downstream Products

• 478910-78-0 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5,6,4'-trimethoxybiphenyl-2-carbaldehyde 
• 1026681-93-5 tert-butyl-[2-(2-ethynyl-5,6,4'-trimethoxy-biphenyl-3-yl)-ethoxy]-diphenyl-silane 
• 478910-91-7 toluene-4-sulfonic acid 2-(2-ethynyl-5,6,4'-trimethoxy-biphenyl-3-yl)-ethyl ester 

Relevant academic research and scientific papers

Total synthesis of the tropoloisoquinoline alkaloid pareitropone via alkynyliodonium salt chemistry and related studies.

The first chemical synthesis of pareitropone, by a route featuring application of alkynyliodonium salt chemistry, is described. The key transform initiates with addition of an alkylidenecarbene, derived by intramolecular nucleophile addition to the alkynyliodonium moiety, to a proximal aromatic ring. This addition delivers a highly strained norcaradiene substructure that rapidly reorganizes to furnish the pareitropone skeleton.