478919-13-0

Basic information

• Product Name: diethyl 2-((1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl)malonate
• Synonyms: diethyl 2-((1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl)malonate
• CAS NO: 478919-13-0
• Molecular Weight: 423.463
• Mol File: 478919-13-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diethyl 2-((1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-((1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl)malonate(478919-13-0)
• EPA Substance Registry System: diethyl 2-((1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl)malonate(478919-13-0)

Safety Data

• Hazardous Substances Data: 478919-13-0(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 105-53-3 diethyl malonate 
• 133332-47-5 2-(cyclopentyloxy)-1-methoxy-4-[(E)-2-nitroethenyl]benzene 
• 141332-74-3 2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene 
• 137-43-9 Cyclopentyl bromide 

Downstream Products

• 85416-75-7 (R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 
• 478919-14-1 (4R)-ethyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-oxopyrrolidine-3-carboxylate 

Relevant articles and documents

Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications

A series of chiral polysulfonate cyclohexyldiamine-Ni(II) catalysts were prepared via sulfur (VI) fluoride exchange click-reactions. The catalysts exhibited good catalytic activity and enantioselectivity in the Michael addition of malonates to nitroalkene

Practical large-scale preparation of (r)-rolipram using chiral nickel catalyst

Antidepressant drug (R)-rolipram was readily prepared on a large scale from isovanilline via a succinct route. The key reaction was carried out using a 1 mol% loading of nickel(II)-bis[(S,S)-N,N-dibenzylcyclohexane-1,2-diamine]Br2 complex as the catalyst.