478919-15-2Relevant academic research and scientific papers
A synthetic γ-amino butyric acid kind of chiral the method for preparing the compound of
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Paragraph 0119-0121, (2017/03/17)
The invention discloses a method for synthesizing a gamma-aminobutyric acid chiral compound. The method comprises the following steps of: adding nitroolefin and malonate to a solvent in the presence of a catalyst A and an additive; carrying out conjugate
Practical large-scale preparation of (r)-rolipram using chiral nickel catalyst
Wen, Lixin,Tang, Feiyu,Ge, Chengsheng,Wang, Xiaodong,Han, Zhi,Wu, Jianyi
experimental part, p. 3288 - 3295 (2012/10/08)
Antidepressant drug (R)-rolipram was readily prepared on a large scale from isovanilline via a succinct route. The key reaction was carried out using a 1 mol% loading of nickel(II)-bis[(S,S)-N,N-dibenzylcyclohexane-1,2-diamine]Br2 complex as the catalyst.
Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram
Barnes, David M.,Wittenberger, Steven J.,Zhang, Ji,Ji, Jianguo,Fickes, Michael G.,Fitzgerald, Michael A.,King, Steven A.,Morton, Howard E.,Plagge, Frederick A.,Preskill, Margo,Wagaw, Seble H.
, p. 13097 - 13105 (2007/10/03)
The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic asymmetric conjugate addition of ketoesters to nitroolefins. Employing just 4 mol % bis(oxazoline)-Mg
