478921-24-3Relevant academic research and scientific papers
Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4- methylanilino)uracils
Zhi, Chengxin,Long, Zheng-Yu,Manikowski, Andrzej,Brown, Neal C.,Tarantino Jr., Paul M.,Holm, Karsten,Dix, Edward J.,Wright, George E.,Foster, Kim A.,Butler, Michelle M.,LaMarr, William A.,Skow, Donna J.,Motorina, Irina,Lamothe, Serge,Storer, Richard
, p. 7063 - 7074 (2007/10/03)
Numerous 3-substituted-6-(3-ethyl-4-methylanilino)uracils (EMAU) have been synthesized and screened for their capacity to inhibit the replication-specific bacterial DNA polymerase IIIC (pol IIIC) and the growth of Gram+ bacteria in culture. Direct alkylat
Methods for synthesizing substituted pyrimidines
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, (2008/06/13)
Methods of preparing N3-substituted-4-pyrimidones are disclosed. The methods include combining a 4-pyrimidone and a non-aqueous base, followed by an alkylating agent, for a time sufficient for the pyrimidone and the alkylating agent to react. Methods of p
N3-substituted 6-anilinopyrimidines and methods to treat-Gram-positive bacterial and mycoplasmal infections
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, (2008/06/13)
Compounds useful for treating Gram-positive bacterial and mycoplasmal infections are disclosed. The compounds have the general formulae shown below.
