478944-09-1Relevant articles and documents
Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity.
Suhara, Yoshitomo,Kittaka, Atsushi,Kishimoto, Seishi,Calverley, Martin J,Fujishima, Toshie,Saito, Nozomi,Sugiura, Takayuki,Waku, Keizo,Takayama, Hiroaki
, p. 3255 - 3258 (2007/10/03)
The 2alpha-methyl-, 2alpha-(3-hydroxypropyl)-, and 2alpha-(3-hydroxypropoxy)-derivatives of the 'double side chain' analogue of 1alpha,25-dihydroxyvitamin D(3) were synthesized using Trost A-ring/CD-ring connective strategy. Regarding the requisite A-ring building blocks, a new, high yield and stereoselective route to the 2alpha-methyl compound starting from D-glucose was developed. All three new analogues showed potent HL-60 cancer cell differentiation activity.