478944-12-6

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 478944-11-5 Benzoic acid (R)-1-((R)-(S)-1-oxiranyl-ethyl)-allyl ester 
• 478944-09-1 Benzoic acid (1R,2S,3S)-3,4-dihydroxy-2-methyl-1-vinyl-butyl ester 
• 3150-15-0 methyl 2,3-anhydro-4,6-O-benzilidene-α-D-mannopyranoside 
• 84170-91-2 methyl 4,6-O-benzylidene-3-deoxy-3-C-methyl-α-D-altropyranoside 
• 79386-70-2 Benzoic acid (2S,3S,4S,5S,6S)-2-bromomethyl-5-hydroxy-6-methoxy-4-methyl-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity.

The 2alpha-methyl-, 2alpha-(3-hydroxypropyl)-, and 2alpha-(3-hydroxypropoxy)-derivatives of the 'double side chain' analogue of 1alpha,25-dihydroxyvitamin D(3) were synthesized using Trost A-ring/CD-ring connective strategy. Regarding the requisite A-ring building blocks, a new, high yield and stereoselective route to the 2alpha-methyl compound starting from D-glucose was developed. All three new analogues showed potent HL-60 cancer cell differentiation activity.