478946-59-7Relevant academic research and scientific papers
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
Pitts, William J,Guo, Junqing,Dhar, T G Murali,Shen, Zhongqi,Gu, Henry H,Watterson, Scott H,Bednarz, Mark S,Chen, Bang Chi,Barrish, Joel C,Bassolino, Donna,Cheney, Daniel,Fleener, Catherine A,Rouleau, Katherine A,Hollenbaugh, Diane L,Iwanowicz, Edwin J
, p. 2137 - 2140 (2007/10/03)
A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase
Dhar,Liu, Chunjian,Pitts, William J.,Guo, Junquing,Watterson, Scott H.,Gu, Henry,Fleener, Catherine A.,Rouleau, Katherine,Sherbina,Barrish, Joel C.,Hollenbaugh, Diane,Iwanowicz, Edwin J.
, p. 3125 - 3128 (2007/10/03)
A series of heterocyclic replacements for the central diamide moiety of 1, a potent small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH) were explored. The synthesis and the structure-activity relationships (SARs), derived from in vitro
