478968-48-8

Upstream product

• 77-78-1 dimethyl sulfate 
• 478968-45-5 ethyl 1-acetyl-3-hydroxy-1H-pyrazole-4-carboxylate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 178424-17-4 1-(tert-butyl) 4-ethyl 3-hydroxy-1H-pyrazole-1,4-dicarboxylate 
• 7251-53-8 3-hydroxypyrazole-4-carboxylic acid ethyl ester 

Downstream Products

• 103626-04-6 ethyl 3-methoxy-1-methyl-1H-pyrazole-4-carboxylate 
• 945954-97-2 ethyl 3-methoxy-1-phenyl-1H-pyrazole-4-carboxylate 
• 113100-56-4 3-methoxy-1-methyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

The invention is concerned with the compounds of formula I and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS

5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly usef

Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.

The synthesis and in vivo activities of a series of substituted pyrazole-4-carboxylic acids as hypoglycemic agents are described. Modelization of some potent compounds, comparatively to the metformine, presents certain analogies permitting to predict the design of some novel antidiabetic drugs.