103626-04-6Relevant articles and documents
USE OF MORPHINAN DERIVATIVES FOR TREATMENT OF OPIOID RECEPTOR AGONIST-RELATED DISEASES
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, (2019/08/01)
The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid δ receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid δ receptor-related diseases (for example, headache) can be treated or prevented.
MORPHINAN DERIVATIVE
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Paragraph 0222; 0223, (2018/03/02)
A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(=O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.
1,3-Dimethylbutyl carboxanilides for controlling undesirable micro-organisms
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, (2008/06/13)
This invention relates to novel 1,3-dimethylbutylcarboxanilides of the formula (I) in which A, R1 and R2 are as defined in the disclosure, to a plurality of processes for preparing these compounds and their use for controlling unwant
1,3-DIMETHYLBUTYL CARBOXANILIDES FOR CONTROLLING UNDESIRABLE MICRO-ORGANISMS
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Page/Page column 44, (2010/02/11)
The invention relates to novel 1,3-dimethylbutyl carboxanilides of formula (I), in which A, R1 and R2 are defined as cited in the description, to several methods for producing said substances, to their use for controlling undesirable
Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.
Cottineau, Bertrand,Toto, Patrick,Marot, Christophe,Pipaud, Aline,Chenault, Jacques
, p. 2105 - 2108 (2007/10/03)
The synthesis and in vivo activities of a series of substituted pyrazole-4-carboxylic acids as hypoglycemic agents are described. Modelization of some potent compounds, comparatively to the metformine, presents certain analogies permitting to predict the design of some novel antidiabetic drugs.