478977-50-3

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 72985-19-4 5-(bromomethyl)-2-methylbenzoic acid 

Downstream Products

• 1097778-02-3 1,1-dimethylethyl 2-methyl-5-({5-[(phenylmethyl)oxy]-1H-indol-1-yl}methyl)benzoate 
• 522632-91-3 2-Methyl-5-[(2R,3R,4S,5R,6S)-4,5,6-tris-benzyloxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-ylmethoxymethyl]-benzoic acid (2R,4aR,6S,7R,8S,8aR)-7-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 522633-05-2 5-[(2R,3R,4S,5R,6S)-4,5-Bis-benzyloxy-6-methoxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-ylmethoxymethyl]-2-methyl-benzoic acid (2R,4aR,6S,7R,8S,8aR)-7-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 522632-92-4 2-Methyl-5-((2R,3R,4S,5R,6S)-4,5,6-tris-benzyloxy-3-hydroxy-tetrahydro-pyran-2-ylmethoxymethyl)-benzoic acid (2R,4aR,6S,7R,8S,8aR)-7-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 522632-93-5 benzyl 6,3'-O-(2-methyl-5-methylene-benzoyl)-(2-O-benzyl-4,6-O-benzylidene-β-D-glucopyranosyl)-(1 - 4)-2,3-di-O-benzyl-α-D-glucopyranoside 
• 522633-06-3 5-((2R,3R,4S,5R,6S)-4,5-Bis-benzyloxy-3-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxymethyl)-2-methyl-benzoic acid (2R,4aR,6S,7R,8S,8aR)-7-benzyloxy-6-ethylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 478977-52-5 tert-butyl 5-[methyl 2,3-di-O-benzyl-4-O-levulinoyl-α-D-glucopyranosid-6-yloxymethyl]-2-methylbenzoate 
• 478977-54-7 5-[methyl 2,3-di-O-benzyl-4-O-levulinoyl-α-D-glucopyranosid-6-yloxymethyl]-2-methylbenzoic acid 
• 522633-04-1 tert-butyl-5-[methyl 2,3-di-O-benzyl-α-D-glucopyranosid-6-yloxymethyl]-2-methylbenzoate 
• 478977-53-6 methyl O-[2-O-benzyl-3-O-(3-hydroxycarbonyl-4-methylbenzyl)-4,6-O-benzylidene-β-D-glucopyranosyl]-(1 - 4)-[2,3-di-O-benzyl-6-O-(3-methoxycarbonyl-4-methyl)benzyl]-α-D-glucopyranoside 
• 522632-88-8 tert-butyl 5-[benzyl 2,3-di-O-benzyl-4-O-(4-methoxybenzyl)-α-D-glucopyranosid-6-yloxymethyl]-2-methylbenzoate 
• 72985-19-4 5-(bromomethyl)-2-methylbenzoic acid 

Relevant academic research and scientific papers

FARNESOID X RECEPTOR AGONISTS

The present invention relates to famesoid X receptors (FXR, NR1H4) FXR is a member of the nuclear receptor class of ligand-activate transcription factors More particularly, the present invention relates to compounds useful as agonists for FXR, pharmaceutical formulations comprising such compounds, and therapeutic use of the same Novel isoxazole compounds are disclosed as part of pharmaceutical compositions for the treatment of a condition mediated by decreased FXR activity, such as obesity, diabetes, cholestatic liver disease, liver fibrosis, and metabolic syndrome

Reiterative intramolecular glycosylation supported by a rigid spacer

This paper describes a synthesis of trisaccharide 1 by reiterative intramolecular glycosidation with 5-(bromomethyl)-2-methylbenzoic acid (5a) as starting material for the generation of a rigid spacer. Intramolecular glycosidation of donor-acceptor-tethered compound 24 yielded disaccharide 25. Transesterification of 25 afforded 26, which generated a new linking centre for the next spacer. Repetition of the previous cycle on 26 yielded trisaccharide 1, which again presents an extension point for the synthesis of higher saccharides. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2003.