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479-44-7

1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one, also known as Flavopiridol, is a naturally occurring alkaloid and a potent inhibitor of cyclin-dependent kinases (CDKs). It is a yellow crystalline compound with a molecular formula of C19H13O6 and a molecular weight of 343.3 g/mol. Flavopiridol has gained significant attention in the field of cancer research due to its ability to arrest cell cycle progression and induce apoptosis in various cancer cell lines. The compound is derived from the plant Dendrobium chrysanthum and has been extensively studied for its potential therapeutic applications in the treatment of various types of cancer, including breast, lung, and colon cancer. Its mechanism of action involves the inhibition of CDKs, which are key regulators of cell cycle progression, leading to the prevention of cancer cell growth and division.

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  • 479-44-7 Structure

  • Basic information

    1. Product Name: 1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one
    2. Synonyms: 1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one;Ravenelin
    3. CAS NO:479-44-7
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 479-44-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one(479-44-7)
    11. EPA Substance Registry System: 1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one(479-44-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 479-44-7(Hazardous Substances Data)

479-44-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 479-44-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 479-44:
(5*4)+(4*7)+(3*9)+(2*4)+(1*4)=87
87 % 10 = 7
So 479-44-7 is a valid CAS Registry Number.

479-44-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4,8-trihydroxy-3-methylxanthen-9-one

1.2 Other means of identification

Product number -
Other names 1,4,8-Trihydroxy-3-methyl-9H-xanthen-9-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:479-44-7 SDS

479-44-7Downstream Products

479-44-7Relevant articles and documents

Construction of Highly Functionalized Xanthones via Rh-Catalyzed Cascade C-H Activation/ O-Annulation

Nale, Sagar D.,Maiti, Debabrata,Lee, Yong Rok

supporting information, p. 2465 - 2470 (2021/04/05)

A facile and efficient strategy for obtaining functionalized and multihydroxylated xanthones via Rh catalysis under redox-neutral conditions is developed. Diverse salicylaldehydes bearing heterocycles, aromatics, and fused aromatics can be rapidly coupled with 1,4-benzoquinones or 1,4-hydroquinones to afford valuable xanthones via cascade C-H/O-H functionalization and annulation. This protocol provides a rapid synthetic approach to obtain biologically active materials through late-stage functionalization and prepares natural products such as subelliptenone, pruniflorone N, and ravenelin.

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