479035-89-7

Upstream product

• 476209-86-6 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester 
• 10387-40-3 potassium thioacetate 
• 1028289-72-6 (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester 

Downstream Products

• 476209-98-0 N⁴-benzoyl-1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]-5-fluorocytosine 
• 476209-96-8 (+)-N⁴-benzoyl-1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-D-ribofuranosyl]-5-fluorocytosine 
• 476210-32-9 (+)-9-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-D-ribofuranosyl]-6-chloro-2-fluoropurine 
• 476210-22-7 9-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]-6-chloropurine 
• 476210-00-1 1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]thymine 
• 476210-06-7 N⁴-benzoyl-1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-D-ribofuranosyl]-5-fluorocytosine 
• 476210-02-3 1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil 
• 476210-04-5 N⁴-benzoyl-1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-D-ribofuranosyl]cytosine 
• 476210-35-2 9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-D-ribofuranosyl]-6-chloropurin-2-amine 
• 476210-09-0 1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-D-ribofuranosyl]thymine 
• 476210-11-4 1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-D-ribofuranosyl]uracil 
• 1026490-43-6 N-[5-Fluoro-1-((2R,5S)-3-fluoro-5-hydroxymethyl-2,5-dihydro-thiophen-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 476210-45-4 (3S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-dihydro-thiophen-2-one 
• 145887-11-2 (3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-dihydro-thiophen-2-one 

Relevant academic research and scientific papers

2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.

Both D- and L-2'-fluoro-4'-thio-2',3'-unsaturated nucleosides were synthesized and their anti-HIV activity against the drug sensitive virus and lamivudine-resistant mutant (M184V) were evaluated. In vitro antiviral evaluation indicated that the L-isomers

Stereoselective synthesis and antiviral activity of d-2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro-4 ′-thionucleosides

As 2′,3′-didehydro-2′,3′-dideoxy-2′ -fluoronucleosides have exhibited interesting antiviral effects against HIV-1 as well as HBV, it is of interest to synthesize the isosterically substituted 4′-thionucleosides in which 4′-oxygen is replaced by a sulfur a