4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

Base Information

Chemical Name:4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester
CAS No.:479035-89-7
Molecular Formula:C₂₄H₃₁FO₄SSi
Molecular Weight:462.658
Hs Code.:

Synonyms:4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

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Chemical Property of 4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

Chemical Property:

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Technology Process of 4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

There total 4 articles about 4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 476209-86-6
5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

: 10387-40-3
potassium thioacetate

: 479035-89-7
4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1021/jm020246+

Reference yield:

: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one

: 479035-89-7
4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C

2: NaOH

3: I₂; PPh₃; imidazole

4: dimethylformamide

With 1H-imidazole; sodium hydroxide; hydrogen; iodine; triphenylphosphine; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-120021965

Reference yield:

: 1028289-72-6
(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

: 479035-89-7
4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 7.52 g / I₂; imidazole; PPh₃ / toluene / 4 h / 60 °C

2: 87 percent / dimethylformamide / 8 h / 20 °C

With 1H-imidazole; iodine; triphenylphosphine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm020246+