479073-73-9

Upstream product

• 479073-75-1 (15S,16S)-15,16-Dihydroxy-octadeca-6,9,12-triynoic acid methyl ester 
• 479073-85-3 (3S,4S)-7-(trimethylsilyl)hept-6-yne-3,4-diol 
• 479073-81-9 ((E)-Hept-4-en-1-ynyl)-trimethyl-silane 
• 479073-77-3 (3S,4S)-Hept-6-yne-3,4-diol 
• 209860-37-7 methyl 11-hydroxyundeca-6,9-diynoate 
• 209860-40-2 11-Bromo-undeca-6,9-diynoic acid methyl ester 
• 56909-02-5 methyl hept-6-ynoate 
• 7348-71-2 (E)-1-bromo-2-pentene 
• 479073-89-7 (6Z,9Z,12Z)-(15S,16S)-15,16-Dihydroxy-octadeca-6,9,12-trienoic acid methyl ester 

Relevant academic research and scientific papers

First total synthesis of natural aplyolides C and E, ichthyotoxic macrolides isolated from the skin of the marine mollusc Aplysia depilans

A convergent pathway is described for the synthesis of the marine macrolides aplyolides C 4 and E 5. The key fragment 8 was prepared stereoselectively by Sharpless asymmetric dihydroxylation of eneyne 13.