479076-90-9Relevant academic research and scientific papers
HETEROARYL INHIBITORS OF PAD4
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Paragraph 00261-00262, (2018/03/28)
The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
Triflic Anhydride Promoted Intramolecular Cyclization of N -Aryl Cinnamides: Access to Polysubstituted Quinolin-2(1 H)-ones
Zhang, Qian,Yuan, Jingwen,Yu, Mangfei,Zhang, Rui,Liang, Yongjiu,Huang, Peng,Dong, Dewen
, p. 4996 - 5002 (2017/10/06)
A facile and efficient synthesis of polysubstituted quinolin-2(1 H)-ones is developed via intramolecular cyclization of readily available N -aryl cinnamides promoted by triflic anhydride in N, N -dimethyl trifluoroacetamide (DTA) under mild conditions.
Silver-catalyzed radical tandem cyclization: An approach to direct synthesis of 3-acyl-4-arylquinolin-2(1 H)-ones
Mai, Wen-Peng,Sun, Gang-Chun,Wang, Ji-Tao,Song, Ge,Mao, Pu,Yang, Liang-Ru,Yuan, Jin-Wei,Xiao, Yong-Mei,Qu, Ling-Bo
, p. 8094 - 8102 (2015/03/18)
A silver-catalyzed efficient and practical synthesis of 3-acyl-4-arylquinolin-2(1H)-ones or 3-acyl-4-aryldihydroquinolin-2(1H)-ones through intermolecular radical addition/cyclization in aqueous solution is reported. This method provides a novel, highly e
Solvent-free synthesis and antibacterial studies of some quinolinones
Subashini, Radhakrishnan,Khan, Fazlur-Rahman Nawaz
experimental part, p. 485 - 489 (2012/06/16)
Solvent-free, microwave-induced condensation of 2-aminoaryl alkyl ketones and ethyl 3-oxobutanoate in the presence of amberlite Na sr1L gave quinolinones in high yield when compared to other catalysts. Further, N-alkylation of the quinolinones was carried
