479197-63-2

Upstream product

• 479197-62-1 (3-methoxy-2-vinyl-phenyl)-methanol 
• 121224-35-9 (S)-(-)-1-amino-2-(1'-methoxy-1'-methylethyl)pyrrolidine 
• 64957-80-8 3-methoxy-2-vinylbenzoic acid 
• 775-16-6 N-benzyl-3-pyrrolidinone 
• 479197-59-6 1-bromomethyl-3-methoxy-2-vinyl-benzene 
• 479197-60-9 [1-Benzyl-pyrrolidin-(3E)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine 

Relevant academic research and scientific papers

Regio- and enantioselective alkylation of a N-protected pyrrolidin-3-one using Enders' chiral hydrazone method: A key step towards a new asymmetric total synthesis of (-)-quinocarcin and related analogues

The synthesis of C-4-alkylated pyrrolidin-3-one 5 was achieved by regio- and diastereoselective alkylation of chiral hydrazone 8 with electrophile 7 followed by selective deprotection. Highly functionalised compound 5 is the first key intermediate in our approach towards a new asymmetric total synthesis of (-)-quinocarcin (1) and related structural analogues 2 and 3.