479206-20-7

Basic information

• Product Name: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)
• Synonyms: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI);1-AMINO-2,3-DIHYDRO-1H-INDEN-4-OL
• CAS NO: 479206-20-7
• Molecular Formula: C9H11NO
• Molecular Weight: 149.18974
• Product Categories: AMINEPRIMARY;ALCOHOL
• Mol File: 479206-20-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)(479206-20-7)
• EPA Substance Registry System: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)(479206-20-7)

Safety Data

• Hazardous Substances Data: 479206-20-7(Hazardous Substances Data)

Usage

General Description

1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI) is a chemical compound with the molecular formula C9H11NO. It is a derivative of indole, which is a heterocyclic aromatic organic compound. 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI) has a hydroxyl group (OH) and an amino group (NH2) attached to the indene ring, giving it both hydrophilic and basic properties. The compound can be used in the synthesis of pharmaceuticals and agrochemicals due to its potential biological activities, such as serving as a building block for the synthesis of various heterocyclic compounds with pharmacological properties. The compound may also have applications in the field of organic chemistry and medicinal chemistry due to its unique structure and functional groups, making it a versatile building block for the development of various compounds with potential biological activities.

Upstream product

• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 103441-70-9 4-hydroxy-indan-1-one oxime 
• 103441-70-9 4-hydroxy-indan-1-one oxime 

Downstream Products

• 1201362-27-7 2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

5,7-DIHYDRO-6H-PYRROLO[2,3-D]PYRIMIDIN-6-ONE DERIVATIVES FOR MARK INHIBITION

Compounds of formula I: are potent and selective inhibitors of microtubule affinity regulating kinase (MARK), and hence find use in treatment of Alzheimer's disease and other conditions associated with hyperphosphorylation of tau.

Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives

To developed a novel cerebroprotective agent with central nervous system (CNS) stimulating activity, a series of 1-amino-7-hydroxyindan derivatives was synthesized, and their effects on the survival time of mice under hypoxic conditions were tested.CNS-stimulating activity was also evaluated by examining the promotional effect on the recovery from cerebral concussion induced coma in mice.Several compounds prolonged the survival time of mice in hypoxic conditions at a dose of 30 mg/kg (sc or ip) and 100 mg/kg (po).They also exhibited the promotional effects on recovery from coma at a dose of 100 mg/kg po.The three most potent compounds in both tests, 1-amino-7-hydroxy-6-(1-methylpropyl)indan (20), 1-amino-7-hydroxy-4,6-dimethyl-2-phenylindan (30), and 1-amino-7-hydroxy,2,2,4,6-tetramethylindan (35) were selected for further investigations.Structure-activity relationships were also discussed.