479213-87-1

Upstream product

• 536-74-3 phenylacetylene 
• 591-31-1 3-methoxy-benzaldehyde 
• 932-88-7 1-iodo-2-phenylethyne 
• 591-50-4 iodobenzene 
• 179248-84-1 1-(3-methoxyphenyl)prop-2-yn-1-ol 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 

Downstream Products

• 22966-24-1 (E)-1-(3-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 887331-19-3 1-methoxy-3-[1-(phenylethynyl)but-3-enyl]benzene 
• 24475-94-3 1-(3-methoxyphenyl)-3-phenylprop-2-yn-1-one 
• 1214890-77-3 2-(1-(3-methoxyphenyl)-3-phenylprop-2-ynyl)-4,6-dimethylphenol 
• 1214890-83-1 1-(1-(3-methoxyphenyl)-3-phenylprop-2-ynyl)naphthalen-2-ol 
• 944771-29-3 4-(3-methoxyphenyl)-2-phenylpyrano[3,2-c]chromen-5(4H)-one 
• 15101-69-6 3-phenyl-6-methoxy-1H-indene 
• 1365162-67-9 (Z)-1-(3-methoxyphenyl)-3-phenylprop-2-yn-1-one O-methyl oxime 
• 1616956-32-1 4-fluoro-3-(3-methoxyphenyl)-5-phenylisoxazole 
• 25856-12-6 3-(3-methoxyphenyl)-5-phenylisoxazole 
• 76106-76-8 1-(3-methoxyphenyl)-3-phenylpropane-1-one 

Relevant academic research and scientific papers

Synthesis of quinazoline based chiral ligands and application in the enantioselective addition of phenylacetylene to aldehydes

Five novel 4-phenylquinazolinols were synthesised in three steps. Their application as ligands in the titanium tetraisopropoxide promoted catalytic enantioselective addition of phenylacetylene to a variety of aldehydes gave propargylic alcohols. Under the

DBU-Catalyzed Rearrangement of Secondary Propargylic Alcohols: An Efficient and Cost-Effective Route to Chalcone Derivatives

A 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed rearrangement of diarylated secondary propargylic alcohols to give α,β-unsaturated carbonyl compounds has been developed. The typical 1,3-transposition of oxy functionality, characteristic of Mayer-Schuster rearrangements, is not observed in this case. A broad substrate scope, functional-group tolerance, operational simplicity, complete atom economy, and excellent yields are among the prominent features of the reaction. Additionally, the photophysical properties and crystal-structure-packing behavior of selected compounds were investigated and found to be of interest.

Catalytic claisen rearrangement by intercepting ketenimines with propargylic alcohols: A strategy to generate and transform ketenimines from radicals

An efficient strategy for facilitating the cross-coupling of two radicals has been established via the coordination of a radical with a metal catalyst. This strategy provides a remarkable ability to harness the reactivity of nitrile-containing azoalkanes and enables a novel cascade reaction with nitrile-containing azoalkanes and propargylic alcohols to be established. By using this reaction, a range of acetylenic and allenic amides were obtained that provides a versatile platform for further derivatizations.

Highly regioselective gold-catalyzed formal hydration of propargylic: Gem -difluorides

Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.

Palladium-catalyzed nucleophilic substitution of propargylic carbonates and meldrum's acid derivatives

The palladium-catalyzed reaction of propargylic carbonates with Meldrum's acid derivatives proceeds smoothly in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give substitution products. The substitution products can be

Direct synthesis of 4-fluoroisoxazoles through gold-catalyzed cascade cyclization-fluorination of 2-alkynone O-methyl oximes

A tandem protocol for the synthesis of fluorinated isoxazoles has been developed via catalytic intramolecular cyclizations of 2-alkynone O-methyl oximes and ensuing fluorination. The reactions proceed smoothly at room temperature in the presence of 5 mol

A convenient approach to β-heteroarylated (C-N bond) ketones from Cs2CO3 promoted reaction between propargyl alcohols and nitrogen-heterocycles

An efficient and direct approach to β-heteroarylated (C-N bond) ketones is demonstrated. Base promoted redox isomerization of propargyl alcohol to α,β-unsaturated ketone followed by conjugate addition to NH-heteroarenes affords a wide range of β-heteroarylated ketones in good to excellent yields. Aryl, heteroaryl, alkyl C(sp), and terminal alkynes containing unactivated propargyl alcohols effectively undergo redox-isomerization conjugate addition (RICA) with NH-heteroarenes. Reaction of 3-substituted pyrazoles or indazole with propargyl alcohols enables highly regioselective products. A diverse range of NH-bearing nucleophiles such as: pyrazoles, imidazole, triazoles, pyrrole, indoles and aniline participate in this reaction and deliver the corresponding β-heteroarylated ketones.

P(PhCH2NCH2CH2)3N: An efficient Lewis base catalyst for the synthesis of propargylic alcohols and Morita-Baylis-Hillman adducts via aldehyde alkynylation

(Chemical Equation Presented) Proazaphosphatrane P(PhCH2NCH 2CH2)3N (1a) is an efficient catalyst for the addition of aryl trimethylsilyl alkynes to a variety of aromatic, aliphatic, and heterocyclic aldehydes i

Au(PPh3)Cl-AgSbF6-catalyzed rearrangement of propargylic 1,3-dithianes: Formation of 8-membered 1,3-bisthio-substituted cyclic allenes

Au(PPh3)Cl-AgSbF6-catalyzed rearrangement of propargylic 1,3-dithiane leads to the formation of 8-membered dithio-substituted cyclic allenes, which are remarkably stable. The Royal Society of Chemistry 2009.

Catalytic enantioselective addition of terminal alkynes to aromatic aldehydes using zinc-hydroxyamide complexes

A mandelamide ligand, derived from (S)-mandelic acid and (S)-phenylethanamine, catalyzes the addition of aryl-, alkyl- and silyl-alkynylzinc reagents to aromatic and heteroaromatic aldehydes with good yields and good to high enantioselectivities.