479232-57-0

Usage

Uses

TC OT 39 is a non-peptide oxytocin agonist.

Upstream product

• 73831-13-7 4-cyano-3-methylbenzoic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 479234-51-0 4-(1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester 
• 479234-53-2 4-(1-benzyloxycarbonyl-pyrrolidine-2-carbothioyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester 
• 479234-55-4 benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate 
• 479234-62-3 2-methyl-4-(1-methyl-1,3a,4,5,10,10a-hexahydrobenzo[b]-pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzonitrile 
• 479234-83-8 1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine 
• 1160759-52-3 4-cyano-3-methylbenzoyl chloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 74772-07-9 ethyl 1-methyl-5-<(2-nitrophenyl)amino>-pyrazole-4-carboxylate 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 87295-97-4 5,10-diidro-1-metilpirazolo<3,4-b><1,5>benzodiazepin-4(1H)-one 
• 749226-94-6 5-(2-amino-phenylamino)-1-methyl-1H pyrazole-4-carboxylic acid ethyl ester 
• 67832-11-5 4-bromo-2-methylbenzonitrile 

Relevant academic research and scientific papers

Subtlety of the Structure-Affinity and Structure-Efficacy Relationships around a Nonpeptide Oxytocin Receptor Agonist

Very few nonpeptide oxytocin agonists have currently been reported, and none of them seem suitable for the in vivo investigation of the oxytocin mediated functions. In an attempt to rationalize the design of better tools, we have systematically studied the structural determinants of the affinity and efficacy of representative ligands of the V1a, V2, and OT receptor subtypes. Despite apparently obvious similarity between the ligand structures on one hand, and between the receptor subtypes on the other hand, the binding affinity and the functional activity profiles of truncated and hybrid ligands highlight the subtlety of ligand-receptor interactions for obtaining nonpeptide OT receptor agonists.

Non-peptide oxytocin agonists

The first non-peptide, low molecular weight agonists of the hormone oxytocin (OT) are reported. The most potent compound, 39, showed an EC 50 = 33 nM and was selective for the OT receptor. A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).