479234-76-9

Upstream product

• 189069-17-8 (2S,4R)-methyl 4-methoxypyrrolidine-2-carboxylate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 479234-92-9 (4-aminomethyl-3-chloro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone 
• 74733-30-5 methyl 4-Bromomethyl-3-chlorobenzoate 
• 785040-42-8 [2-chloro-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-benzyl]-carbamic acid tert-butyl ester 
• 165528-69-8 4-(tert-Butyloxycarbonylaminomethyl)-3-chlorobenzoic Acid 
• 940062-11-3 4-aminomethyl-3-chlorobenzoic acid methyl ester 
• 56525-63-4 methyl 3-chloro-4-methyl-benzoate 

Downstream Products

• 479234-81-6 (2S,4R)-1-[2-Chloro-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-benzylcarbamoyl]-4-methoxy-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Non-peptide oxytocin agonists

The first non-peptide, low molecular weight agonists of the hormone oxytocin (OT) are reported. The most potent compound, 39, showed an EC 50 = 33 nM and was selective for the OT receptor. A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).