56525-63-4

Basic information

• Product Name: Methyl 3-chloro-4-methylbenzoate
• Synonyms: METHYL 3-CHLORO-4-METHYLBENZOATE;Methyl4-Methyl-3-Chlorobenzoate;Methyl 3Chioro-4-Methyl benzoate;3-Chloro-4-methylbenzoic acidmethylester;Methyl 3-chloro-4-me;Methyl 3-chloro-4-methylbenzoate 97%;2-Chloro-4-(methoxycarbonyl)toluene;3-Chloro-4-methylbenzoic Acid Methyl Ester Methyl 3-Chloro-p-toluate 3-Chloro-p-toluic Acid Methyl Ester
• CAS NO: 56525-63-4
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Product Categories: Esters;Phenyls & Phenyl-Het
• Mol File: 56525-63-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 28-29°C
• Boiling Point: 68 °C
• Flash Point: 119-120°C/10mm
• Appearance: /
• Density: 1.186 cm³
• Vapor Pressure: 0.0174mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 3-chloro-4-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-chloro-4-methylbenzoate(56525-63-4)
• EPA Substance Registry System: Methyl 3-chloro-4-methylbenzoate(56525-63-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• Hazardous Substances Data: 56525-63-4(Hazardous Substances Data)

Usage

Chemical Properties

White or red powder

InChI:InChI=1/C9H9ClO2/c1-6-3-4-7(5-8(6)10)9(11)12-2/h3-5H,1-2H3

Upstream product

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 2458-12-0 3-amino-p-toluic acid 
• 144-55-8 sodium hydrogencarbonate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 95-73-8 2,4-dichlorotoluene 
• 615-62-3 3-chloro-4-methylphenol 
• 5162-82-3 3-chloro-4-methylbenzoic acid 

Downstream Products

• 74733-30-5 methyl 4-Bromomethyl-3-chlorobenzoate 
• 1392467-24-1 4-(bis(2,2,2-trifluoroethoxy)methyl)-3-chlorobenzoic acid 
• 1134777-59-5 methyl 3-chloro-4-(dibromomethyl)benzoate 
• 21324-01-6 3-chloro-5-iodo-4-methylbenzoic acid methyl ester 
• 17790-62-4 2-chloro-4-isopropenyl-1-methyl-benzene 
• 1204738-06-6 4-azidomethyl-3-chlorobenzoic acid methyl ester 
• 74733-26-9 methyl 3-chloro-4-formyl-benzoate 
• 467439-51-6 4-(2-{(R)-2-[(S)-2-((S)-4-Carboxy-2-isobutoxycarbonylamino-butyrylamino)-4-methyl-pentanoylamino]-3-mercapto-propionylamino}-ethyl)-3-chloro-benzoic acid methyl ester 

Relevant articles and documents

GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

Cobalt-catalyzed methoxycarbonylation of substituted dichlorobenzenes as an example of a facile radical anion nucleophilic substitution in chloroarenes

A thorough mechanistic study on cobalt-catalysed direct methoxycarbonylation reactions of chlorobenzenes in the presence of methyl oxirane on a wide range of substrates, including poly-and monochloro derivatives with multiple substituents, is reported. The results demonstrate that the reaction is potentially useful as it proceeds under very mild conditions (t = 62 °C, PCO = 1 bar) and converts aryl chlorides to far more valuable products (especially ortho-substituted benzoic acids and esters) in high yields. This transformation also offers another opportunity for the utilization of environmentally harmful polychlorinated benzenes and biphenyls (PCBs). This study is the first to discover an unexpected universal positive ortho-effect: the proximity of any substituent (including Me, Ph, and MeO groups and halogen atoms) to the reaction centre accelerates the methoxycarbonylation in chlorobenzenes. The effect of the ortho-substituents is discussed in detail and explained in terms of a radical anion reaction mechanism. The advantages of the methoxycarbonylation as a model for the mechanistic study of radical anion reactions are also illustrated.

Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists

A series of 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoic acids and 4-({2-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)benzoic acids were synthesized and evaluated for their EP receptor affinities and EP1 receptor anta