479408-32-7

Upstream product

• 479408-27-0 8-(N₂-aminopyrene)-O₆-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N₂-dimethoxytrityl-2'-deoxyguanosine 
• 479408-23-6 O⁶-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2′-deoxyguanosine 
• 479408-22-5 O⁶-benzyl-8-bromo-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 479408-21-4 3',5'-O,O'-bis(tert-butyldimethylsilyl)-8-bromo-2'-deoxyguanosine 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 603994-27-0 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine 
• 603994-26-9 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(8-azido-6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 603994-32-7 (2R,3S,5R)-5-(8-Amino-6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol 
• 1714-29-0 1-bromopyrene 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1174406-51-9 C₃₃H₂₈N₆O₄ 
• 85989-43-1 N-(deoxyguanosin-8-yl)-1-aminopyrene 

Relevant academic research and scientific papers

Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes

Two different approaches to synthesize oligonucleotides containing the 2′-deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield. Copyright Taylor & Francis Group, LLC.

A practical approach for the chemical synthesis of 2′-deoxyguanosine-C8 adducts with mutagenic/carcinogenic amino- or nitro-arenes

Synthetic methods for the preparation of 2′-deoxyguanosine-C8 (dG-C8) adducts with several mutagenic and carcinogenic amino- or nitro-arenes were developed using the palladium-mediated cross-coupling reaction of protected 8-amino-dG with bromoarenes in ar

Preparation of C8-amine and acetylamine adducts of 2′-deoxyguanosine suitably protected for DNA synthesis

(Equation presented) C8-Amine and acetylamine adducts of 2′-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2′-deoxyguanosine derivative, for the selective acetylation of the coup