479414-01-2

Basic information

• Product Name: NH₂-L-Tyr(OBut)-Bu
• Synonyms: NH₂-L-Tyr(OBut)-Bu
• CAS NO: 479414-01-2
• Molecular Weight: 292.422
• Mol File: 479414-01-2.mol

Chemical Properties

• CAS DataBase Reference: NH₂-L-Tyr(OBut)-Bu(CAS DataBase Reference)
• NIST Chemistry Reference: NH₂-L-Tyr(OBut)-Bu(479414-01-2)
• EPA Substance Registry System: NH₂-L-Tyr(OBut)-Bu(479414-01-2)

Safety Data

• Hazardous Substances Data: 479414-01-2(Hazardous Substances Data)

Upstream product

• 403641-27-0 Fmoc-L-Tyr(OBut)-Bu 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 

Downstream Products

• 403641-28-1 NH₂-L-Tle-L-Tyr(OBut)-Bu 

Relevant articles and documents

Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones

Cu-catalyzed enantioselective conjugate additions to acyclic aliphatic enones are reported. The resulting enolates may be functionalized intra- and intermolecularly, leading to the formation of an additional C-C bond. The utility of the present method is not limited to reactions involving Et2Zn; a variety of alkylzincs may be used. Moreover, many of the requisite substrates can be easily accessed through catalytic olefin cross metathesis. Copyright

Efficient Cu-catalyzed asymmetric conjugate additions of alkylzincs to trisubstituted cyclic enones

The first examples of efficient catalytic asymmetric conjugate addition (ACA) of alkylzincs to trisubstituted cyclic enones is disclosed. These Cu-catalyzed reactions proceed efficiently with five- and seven-membered ring substrates to afford the desired products in ≥95% ee. Intermediate enolates can be trapped with alkyl halides to generate a quaternary stereogenic center. The requisite chiral ligand is prepared from commercially available materials and can be used in situ without further purification in the presence of commercial grade (CuOTf)2·PhMe. Copyright