479499-12-2

Upstream product

• 387-89-3 2-(2,2,2-trifluoroacetyl)cyclohexanone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 479499-14-4 (7E)-3,3a,4,5,6,7-hexahydro-7-(4-methoxybenzylidene)-3-(trifluoromethyl)-2,1-isoxazol-3-ol 

Relevant academic research and scientific papers

Condensation of 2-polyfluoroacycloalkanones with aldehydes and dimethylformamide-dimethylacetal

Polyfluorinated 1,3-diketones containing carbocycles react with aldehydes under Lewis-acid catalysis and also with dimethylformamide-dimetylacetal without catalysis, yielding exclusively (E)-configured condensation products involving the methylene group of the carbocycle. Novel trifluoromethylated chromenes are prepared from 2-trifluoroacetylcycloalkanones and salicylaldehyde. The structures of two new compounds, 2-(E)-benzylidene-6-trifluoroacetylcyclohexanone and 4-trifluoroacetyl-2,3-dihydro-1H-xantene, are confirmed by X-ray structure analysis.