479499-37-1

Basic information

• Product Name: (4-fluorobenzylideneamino)acetic acid methyl ester
• Synonyms: (4-fluorobenzylideneamino)acetic acid methyl ester
• CAS NO: 479499-37-1
• Molecular Weight: 195.193
• Mol File: 479499-37-1.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: (4-fluorobenzylideneamino)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluorobenzylideneamino)acetic acid methyl ester(479499-37-1)
• EPA Substance Registry System: (4-fluorobenzylideneamino)acetic acid methyl ester(479499-37-1)

Safety Data

• Hazardous Substances Data: 479499-37-1(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 6000-43-7 2-aminoethanoic acid hydrochloride 

Downstream Products

• 1220974-83-3 methyl (2R,4R,5R)-5-(p-fluorophenyl)-4-phenylsulfonylpyrrolidine-2-carboxylate 
• 1241941-51-4 methyl 5-(4-fluorophenyl)-4-(2,2,2-trifluoroacetyl)-1H-pyrrole-2-carboxylate 
• 1221507-57-8 (2S,3S,5S)-4,4-di-tert-butyl 2-methyl 5-(4-fluorophenyl)-3-phenylpyrrolidine-2,4,4-tricarboxylate 
• 1257079-54-1 methyl (1S,3R,3aS,6aR)-3-(4-fluorophenyl)-octahydro-4-oxocyclopenta[c]pyrrole-1-carboxylate 
• 1286738-48-4 (2'R,3S,4'R,5'R)-methyl 2'-(4-fluorophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate 

Relevant articles and documents

Silver-Mediated [3 + 2] Cycloaddition of Azomethine Ylides with Trifluoroacetimidoyl Chlorides for the Synthesis of 5-(Trifluoromethyl)imidazoles

A silver-mediated [3 + 2] cycloaddition of azomethine ylides with trifluoroacetimidoyl chlorides for the rapid assembly of 5-(trifluoromethyl)imidazoles has been developed. Notable features of the reaction include readily accessible reagents, a broad substrate scope, and high efficiency. The protocol can be successfully applied to construct the analogue of the specific allosteric modulator of GABAA receptors. The silver species could be recycled by a simple operation.

Heterogeneous Catalysis with Basic Compounds to Achieve the Synthesis and C-N Cleavage of Azetidin-2-ones under Microwave Irradiation

The synthesis of azetidin-2-ones with a completely heterogeneous catalysis is reported. The use of basic compounds as solid catalysts allowed for the synthesis of azetidin-2-ones under microwave irradiation without organic additives such as triethylamine. An excellent catalyst for this transformation was Mg-Al hydroxide (MAH). The present methodology offers the advantages of non-hazardous reaction conditions, short reaction times, high yields, and catalyst reusability. Different substitution groups were tested on the imines and acyl chlorides to explore the scope of the reaction. Unconventional N-C4 bond cleavage was detected in azetidin-2-ones. MAH was characterized by N 2 adsorption-desorption, X-ray diffraction (XRD), scanning electron microscopy (SEM), and high-resolution transmission electron microscopy (HR-TEM).

Ag/P-Stereogenic Phosphine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions: A Method to Optically Active Pyrrolidines

A Ag/P-stereogenic phosphine-complex-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with electron-deficient olefins is reported. In this reaction, highly functionalized pyrrolines with a spiro-quaternary stereogenic center were obtained in good yields (up to 99%) with excellent levels of diastereo-(up to >20:1 dr) and enantioselectivities (up to >99% ee). The chirality of adducts was controlled predominantly by the P-stereogenic phosphines.