479586-30-6

Basic information

• Product Name: (R)-3-[(R)-3-tert-Butoxycarbonylamino-4-(2-fluoro-phenyl)-butyryl]-thiazolidine-4-carboxylic acid methyl ester
• CAS NO: 479586-30-6
• Molecular Weight: 426.509
• Mol File: 479586-30-6.mol

Chemical Properties

• CAS DataBase Reference: (R)-3-[(R)-3-tert-Butoxycarbonylamino-4-(2-fluoro-phenyl)-butyryl]-thiazolidine-4-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[(R)-3-tert-Butoxycarbonylamino-4-(2-fluoro-phenyl)-butyryl]-thiazolidine-4-carboxylic acid methyl ester(479586-30-6)
• EPA Substance Registry System: (R)-3-[(R)-3-tert-Butoxycarbonylamino-4-(2-fluoro-phenyl)-butyryl]-thiazolidine-4-carboxylic acid methyl ester(479586-30-6)

Safety Data

• Hazardous Substances Data: 479586-30-6(Hazardous Substances Data)

Upstream product

• 42258-90-2 (R)-thiazolidine-4-carboxylic acid methyl ester 
• 218608-98-1 (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid 

Downstream Products

• 479586-14-6 (R)-3-[(R)-3-tert-Butoxycarbonylamino-4-(2-fluoro-phenyl)-butyryl]-thiazolidine-4-carboxylic acid 

Relevant articles and documents

Potent and selective proline derived dipeptidyl peptidase IV inhibitors

In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50 = 1.9 μM). Optimization of 3 led to compound 37, which is among the most potent and selectiv