479673-49-9

Upstream product

• 154919-93-4 (S)-4-Benzyl-3-[(2S,3R)-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-hexanoyl]-oxazolidin-2-one 
• 87184-99-4 4-tert-butyldimethylsilyloxybutan-1-ol 
• 87184-81-4 4-(tert-butyldimethylsilanyloxy)butanal 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 479673-34-2 (6R, [7R,] [12S,] 13S, [14S,] [19R,] [20R,] [21R,] 22S)-21-(TERT-BUTYLDIMETHYLSILANYLOXY)-7,13, [19-TRIS-(4-METHOXYBENZYLOXY)-6,] 12,14, 20,22-pentamethylhexacosa-2, 4,10, 15,23, 25-hexaenoic acid methyl ester 
• 479673-33-1 (4R, [5R,] 10S, [11S,] 12S, [17R,] [18R,] [19R,] 205)-19-(TERT-BUTYLDIMETHYLSILANYLOXY)-5,11, [17-TRIS-(4-METHOXYBENZYLOXY)-4, 10,] 12,18, 20-pentamethyltetracosa-2,8, 13, 21,23-pentaenoic acid ethyl ester 
• 479673-55-7 (2E,8Z,13Z,21Z)-(4R,5R,10S,11S,12S,17R,18S,19S,20S)-19-(tert-Butyl-dimethyl-silanyloxy)-5,11,17-tris-(4-methoxy-benzyloxy)-4,10,12,18,20-pentamethyl-tetracosa-2,8,13,21,23-pentaen-1-ol 
• 479673-56-8 (2Z,4E,10Z,15Z,23Z)-(6R,7R,12S,13S,14S,19R,20R,21S,22S)-21-Hydroxy-7,13,19-tris-(4-methoxy-benzyloxy)-6,12,14,20,22-pentamethyl-hexacosa-2,4,10,15,23,25-hexaenoic acid methyl ester 
• 479673-57-9 (3Z,5E,11Z,16Z)-(7R,8R,13S,14S,15S,20R,21S,22S)-8,14,20-Tris-(4-methoxy-benzyloxy)-7,13,15,21-tetramethyl-22-((Z)-(S)-1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11,16-tetraen-2-one 
• 479673-53-5 (2E,8Z)-(4R,5R,10S,11S,12S)-13-Hydroxy-5,11-bis-(4-methoxy-benzyloxy)-4,10,12-trimethyl-trideca-2,8-dienoic acid ethyl ester 
• 479673-52-4 (2E,8Z)-(4R,5R,10S)-5-(4-Methoxy-benzyloxy)-10-[(4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-undeca-2,8-dienoic acid ethyl ester 
• 479673-54-6 (2E,8Z)-(4R,5R,10S,11S,12R)-5,11-Bis-(4-methoxy-benzyloxy)-4,10,12-trimethyl-13-oxo-trideca-2,8-dienoic acid ethyl ester 
• 479673-50-2 (E)-(4R,5R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-oct-2-enoic acid ethyl ester 
• 479673-51-3 (E)-(4R,5R)-8-Hydroxy-5-(4-methoxy-benzyloxy)-4-methyl-oct-2-enoic acid ethyl ester 
• 479673-32-0 (E)-(4R,5R)-5-(4-Methoxy-benzyloxy)-4-methyl-8-oxo-oct-2-enoic acid ethyl ester 
• 565228-73-1 (1S,2S,3R,6Z,8S,9S,10S,11Z)-[3,9-bis(4-methoxybenzyloxy)-14-[(2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,8,10-trimethyl-1-[(1S,2Z)-1-methylpenta-2,4-dienyl]tetradeca-6,11-dienyloxy]-tert-butyldimethylsilane 
• 565229-72-3 carbamic acid, (1S,2S,3R,6Z,8S,9S,10S,11Z)-3,9-bis(4-methoxybenzyloxy)-14-[(2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,8,10-trimethyl-1-[(1S,2Z)-1-methylpenta-2,4-dienyl]tetradeca-6,11-dienyl ester 
• 565228-57-1 carbamic acid, (1S,2S,3R,6Z,8S,9S,10S,11Z)-3,9-bis(4-methoxybenzyloxy)-14-[(2S,3S,4S,5R)-4-methoxymethoxy-3,5-dimethyl-6-oxotetrahydropyran-2-yl]-2,8,10-trimethyl-1-[(1S,2Z)-1-methylpenta-2,4-dienyl]tetradeca-6,11-dienyl ester 

Relevant academic research and scientific papers

Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation

(Matrix Presented) Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.

Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents

Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used Wittig reactions to append left and right side chains to a central scaffold and then tested for biological activity. Three of the analogues in the 4-epi-7-d