479681-62-4

Basic information

• Product Name: (R)-1-benzyl-3-isopropylpiperazine-2,5-dione
• Synonyms: (R)-1-benzyl-3-isopropylpiperazine-2,5-dione;(3R)-1-benzyl-3-propan-2-ylpiperazine-2,5-dione
• CAS NO: 479681-62-4
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.308
• Mol File: 479681-62-4.mol

Chemical Properties

• Boiling Point: 498.155°C at 760 mmHg
• Flash Point: 255.075°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: (R)-1-benzyl-3-isopropylpiperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-benzyl-3-isopropylpiperazine-2,5-dione(479681-62-4)
• EPA Substance Registry System: (R)-1-benzyl-3-isopropylpiperazine-2,5-dione(479681-62-4)

Safety Data

• Hazardous Substances Data: 479681-62-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-benzyl-3-isopropylpiperazine-2,5-dione is used as a potential therapeutic agent for the treatment of anxiety and depression. Its central nervous system depressant properties make it a candidate for further research and development in the field of mental health.
Used in Neurological Disorder Treatment:
In the field of neurology, (R)-1-benzyl-3-isopropylpiperazine-2,5-dione is investigated for its potential to alleviate symptoms of various neurological disorders. Its pharmacological profile suggests it may offer benefits in managing such conditions, pending further study and clinical trials.
Used in Drug Development:
As a compound with potential therapeutic applications, (R)-1-benzyl-3-isopropylpiperazine-2,5-dione is also used in the drug development process. Researchers are exploring its properties to determine if it can be formulated into effective medications for a range of conditions, including those affecting the central nervous system.

InChI:InChI=1/C14H18N2O2/c1-10(2)13-14(18)16(9-12(17)15-13)8-11-6-4-3-5-7-11/h3-7,10,13H,8-9H2,1-2H3,(H,15,17)/t13-/m1/s1

Upstream product

• 100-39-0 benzyl bromide 
• 143673-66-9 (R)-3-(1-methylethyl)-piperazine-2,5-one 
• 6306-52-1 L-valine methylester hydrochloride 
• 1492-06-4 methyl (S)-2-(2-chloroacetylamino)-2,3-dimethylbutanoate 
• 100-46-9 benzylamine 

Downstream Products

• 479681-66-8 C₂₂H₂₆N₂O₃C₂₂H₂₆N₂O₃C₈H₆ 
• 479681-64-6 (R)-1-Benzyl-3-isopropyl-4-(4-methoxy-benzyl)-piperazine-2,5-dione 

Relevant articles and documents

Highly efficient enantioselective synthesis of 1,3-disubstituted 2,5-diketopiperazine derivatives via microwave irradiation

Chiral 2,5-diketopiperazine (2,5-DKP) derivatives have a broad range of biological activities in the medicinal field. The synthetic protocols of 1,3-disubstituted 2,5-DKPs via base-catalyzed cyclization of chloroacetamide have been reported. However, there are several drawbacks, such as an overly long reaction time, low to moderate yield, and racemization of the products. The sequence modified herein of 1,3-disubstituted 2,5-DKPs involves microwave-assisted cyclization. It increases yields and reduces reaction time. Furthermore, employing N-PMB protection prevents racemization, which frequently occurs in the base-catalyzed cyclization reaction. Consequently, the rapid synthetic method of enantiomerically pure 1,3-disubstituted 2,5-DKPs via microwave reaction was established successfully.

Homochiral supramolecular polymerization of an "S"-shaped chiral monomer: Translation of optical purity into molecular weight distribution

An "S"-shaped chiral motif of a p-xylylene-bridged bis(cyclic dipeptide) (1), having four hydrogen-bonding amide functionalities, formed a homochiral supramolecular polymer in solution. X-ray crystallography of a slightly modified version of 1 for an enha