4797-76-6Relevant academic research and scientific papers
Method for efficiently preparing quinazolone compounds
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Page/Page column 6, (2017/04/20)
The invention discloses a method for efficiently preparing quinazolone compounds. According to the method, 3-oxyquinazoline and methyl aromatic hydrocarbons are used as substrate, a copper salt is used as a catalyst, 5.5M tert-butyl hydroperoxide in decane is used as an oxidizer, tetrabutyl ammonium iodide and sodium iodide are used as additives, dichloromethane is used as a solvent, and the reaction is carried out at 50-100 DEG C to obtain the quinazolone compounds, wherein the reaction general formula is (1). The 3-oxyquinazoline and methyl aromatic hydrocarbons are subjected to one-step reaction to directly synthesize the quinazolone compounds, and thus, the method has the advantages of direct and simple reaction, low substrate limitation and high reaction efficiency and has wide potential application value.
APPLICATION OF QUARTERNARY PHOSPHONIUM SALTS IN ALKYLATION AND ACYLATION OF N-HYDROXYLACTAMS
Grochowski, Edward,,Boleslawska, Teresa
, p. 615 - 621 (2007/10/02)
Reactions of N-hydroxylactams with alcohols and carboxylic acids in presence of triphenylphosphine and diethyl azodicarboxylate have been described.Contrary to corresponding acyclic amides (hydroxamic acids), cyclic compounds form under these conditions O
