480-36-4

Basic information

• Product Name: Linarin
• Synonyms: LINARIN;BUDDLEOSIDE;BUDDLOSIDE;ACACETIN-7-O-RUTINOSIDE;ACACETIN-7-RUTINOSIDE;7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone;7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one;Buddloside，Linarin
• CAS NO: 480-36-4
• Molecular Formula: C₂₈H₃₂O₁₄
• Molecular Weight: 592.55
• EINECS: 207-547-6
• Product Categories: Tri-substituted Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 480-36-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 258-260°C
• Boiling Point: 885.2 °C at 760 mmHg
• Flash Point: 292.2 °C
• Appearance: /
• Density: 1.62 g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetic Acid (Very Slightly, Heated), Acetonitrile (Slightly), DMSO (Slightly), M
• PKA: 6.11±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Linarin(CAS DataBase Reference)
• NIST Chemistry Reference: Linarin(480-36-4)
• EPA Substance Registry System: Linarin(480-36-4)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 480-36-4(Hazardous Substances Data)

Usage

Uses

Linarine (Diosmin EP Impurity E) is a naturally occurring flavone glycoside that was identified to possess potential sedative and anticonvulsant properties.

Upstream product

• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 4154-21-6 O²,O³,O⁴-triacetyl-O⁶-(tri-O-acetyl-α-L-rhamnopyranosyl)-α-D-glucopyranosyl bromide 
• 520-27-4 diosmin 
• 771480-96-7 3'-O-(1-phenyltetrazol-5-yl)diosmin 

Downstream Products

• 50848-66-3 7,4'-dimethoxy-5-hydroxy-6-iodoflavone 
• 5128-44-9 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 827346-51-0 C₂₈H₃₁BrO₁₄ 
• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 124904-19-4 linarin heptaacetate 

Relevant articles and documents

Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin

Semisynthesis of linarin and acacetin from the Citrus flavonoid diosmin was performed via, as first intermediate, the 3′-O-phenyltetrazolyl ether of diosmin. This paper relates also a semisynthetic access to 6-iodoapigenin derivatives, which are key compounds in the synthesis of some biflavonoids such as robustaflavone.