4802-88-4

Basic information

• Product Name: (2,4-DIOXO-3,4-DIHYDROQUINAZOLIN-1(2H)-YL)ACETIC ACID
• Synonyms: 2-(2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetic acid
• CAS NO: 4802-88-4
• Molecular Formula: C10H8N2O4
• Molecular Weight: 220.18
• Mol File: 4802-88-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.482g/cm³
• Refractive Index: 1.616
• CAS DataBase Reference: (2,4-DIOXO-3,4-DIHYDROQUINAZOLIN-1(2H)-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-DIOXO-3,4-DIHYDROQUINAZOLIN-1(2H)-YL)ACETIC ACID(4802-88-4)
• EPA Substance Registry System: (2,4-DIOXO-3,4-DIHYDROQUINAZOLIN-1(2H)-YL)ACETIC ACID(4802-88-4)

Safety Data

• Hazardous Substances Data: 4802-88-4(Hazardous Substances Data)

Usage

General Description

The chemical "(2,4-Dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetic acid" is a compound with a molecular structure containing a quinazolinone ring and an acetic acid group. It is commonly used in the field of pharmaceutical research as a substance that exhibits potential biological and pharmacological activities. Its structure suggests that it may have relevance in the development of new drugs for various medical conditions. Research on this compound has shown promising results in its ability to interact with biological targets, making it a subject of interest for further investigation in the field of medicinal chemistry.

InChI:InChI=1/C10H8N2O4/c13-8(14)5-12-7-4-2-1-3-6(7)9(15)11-10(12)16/h1-4H,5H2,(H,13,14)(H,11,15,16)

Upstream product

• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 79-08-3 bromoacetic acid 
• 118-92-3 anthranilic acid 
• 96222-36-5 1-Methoxycarbonylmethyl-3,1-benzoxazin-2,4-dion 
• 105234-33-1 (2-carbamoylphenylamino)-acetic acid ethyl ester 
• 88267-57-6 2-methoxycarbonylmethylaminobenzamide 
• 13622-59-8 N-(2-methoxycarbonylphenyl)glycine methyl ester 
• 57384-71-1 1-Ethoxycarbonylmethyl-2H-3,1-benzoxazine-2,4(1H)-dione 
• 112342-50-4 [(2-Carbamoyl-phenyl)-ethoxycarbonyl-amino]-acetic acid methyl ester 
• 105391-90-0 1,2,3,4-Tetrahydro-2,4-dioxo-chinazolin-1-yl-essigsaeureethylester 
• 112342-46-8 1,2,3,4-Tetrahydro-2,4-dioxo-chinazolin-1-yl-essigsaeuremethylester 

Relevant articles and documents

Alkali metal cations control over nucleophilic substitutions on aromatic fused pyrimidine-2,4-[1H,3H]-diones: Towards new PNA monomers

In this paper we report synthesis of a series of aromatic fused pyrimidine-2,4(3H)-dione-1-yl acetic acid and new PNA monomers containing these polycyclic nucleobase analogues. Introduction of a fused aromatic ring onto the 5,6-positions of the pyrimidine-2,4-[1H,3H]-diones brings about the steric effects and the charge delocalization, both weakening the nucleophilic substitutions on the 1- and 3-positions. We found that alkali metal cations play an important role in this alkylation reaction. LiOH brings out a much more efficient alkylation than NaOH does, while KOH nearly does not work on this reaction. Such influences from the alkali metal cations are probably due to that the charge-pairing interactions between the pyrimidine-2,4-dioxide anions and the alkali metal cations rearrange the charge distribution around the whole aromatic system and increase the negative charge distribution on the 1- and 3-nitrogen atoms, which then strengthens the nucleophilic reactivity on these positions.