480439-29-0Relevant academic research and scientific papers
Visible-Light-Driven Neutral Nitrogen Radical Mediated Intermolecular Styrene Difunctionalization
Zhao, Quan-Qing,Li, Man,Xue, Xiao-Song,Chen, Jia-Rong,Xiao, Wen-Jing
supporting information, p. 3861 - 3865 (2019/05/24)
A neutral nitrogen radical-mediation strategy, wherein the existing N-H moiety of substrates serves as a neutral nitrogen radical precursor to enable room-temperature intermolecular radical difunctionalization of styrenes under photoredox catalysis, is reported. The reaction shows high functional group tolerance and substrate scope with respect to both components, giving the corresponding products with generally good yields. Preliminary control experiments and DFT calculations are performed to explain the reaction mechanism.
Straightforward and Sustainable Synthesis of Sulfonamides in Water under Mild Conditions
Eid, Nadim,Karamé, Iyad,Andrioletti, Bruno
supporting information, p. 5016 - 5022 (2018/09/14)
Ideally, a sustainable chemical synthesis should involve the use of non-toxic solvents and reactants, easy separations and purification by energy-efficient processes. In this context, reconsidering the synthesis of widely used drugs is especially timely and should allow important benefits to be obtained in terms of environmental impact. Sulfonamides are pertinent as their synthesis generally requires the use of toxic and/or hard-to-remove solvents such as dichloromethane, DMF and DMSO. In addition, toxic and highly reactive sulfur-containing sources such as sulfonyl chloride are often involved and coupled with amines. Moreover, the latter may exhibit some toxicity and are generally difficult to purify. Herein, we disclose the unprecedented and sustainable synthesis of sulfonamides by using sodium sulfinate as a commercial and stable sulfur source and nitroarenes as the nitrogen-containing reactant. In addition, under the optimized conditions only water is used as a “green” solvent and the products are collected by simple filtration.
Rhodium(iii)-catalyzed coupling of N-sulfonyl 2-aminobenzaldehydes with oxygenated allylic olefins through C-H activation
Yang, Tingting,Zhang, Tao,Yang, Shangdong,Chen, Shanshan,Li, Xingwei
, p. 4290 - 4294 (2014/06/23)
Rh(iii)-catalyzed coupling of N-sulfonyl 2-aminobenzaldehydes with oxygenated allylic olefins via C-H bond activation is described. Diarylketones were obtained through coupling of N-sulfonyl 2-aminobenzaldehydes with 7-oxabenzonorbornadienes. On the other
Synthesis of novel nitrogen-containing ligands for the enantioselective addition of diethylzinc to aldehydes
Fonseca, Maria Hechavarria,Eibler, Ernst,Zabel, Manfred,Koenig, Burkhard
, p. 1989 - 1994 (2007/10/03)
New nitrogen-containing ligands derived from the (1R,2R)-trans-cyclohexanediamine chiral core unit have been synthesized and fully characterized. Their catalytic activity was tested in the asymmetric addition of diethylzinc to aldehydes leading to the res
