480440-23-1

Basic information

• Product Name: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester
• Synonyms: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester
• CAS NO: 480440-23-1
• Molecular Weight: 501.623
• Mol File: 480440-23-1.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester(480440-23-1)
• EPA Substance Registry System: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester(480440-23-1)

Safety Data

• Hazardous Substances Data: 480440-23-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 107-11-9 1-amino-2-propene 

Downstream Products

• 480440-31-1 (S)-2-({(S)-1-[(R)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester 
• 480440-30-0 (S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester 

Relevant articles and documents

Synthesis of β-methyl-β-alanine-L-proline-XAA tripeptides by Yb(OTf)3 catalysed Michael addition of amines to N-crotonyl-L-proline-XAA: A versatile route to cyclic β-methyl-β-alanine-derived tripeptides via ring closing metathesis

N-Crotonyl-L-proline derived peptides can be transformed to the corresponding β-methyl-β-alanine-L-proline peptides by Yb(OTf)3 catalysed Michael addition of aliphatic amines to the crotonyl residue. The Michael adducts derived from addition of allylamine are versatile precursors to the corresponding cyclic peptides obtainable via ring closing metathesis.