480446-87-5

Upstream product

• 5805-57-2 2-Aminomethylbenzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 480446-84-2 3-[(1-ethoxycarbonylmethyl-1H-benzoimidazol-2-ylmethyl)-carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 403652-15-3 Boc-Tic-NH-CH₂-Bid 
• 133703-73-8 tert-butyl (2-((2-aminophenyl)amino)-2-oxoethyl)carbamate 
• 189560-83-6 (1H-Benzimidazol-2-yl-methyl)-carbamic acid tert-butyl ester 
• 99953-00-1 (S)-N-Boc-2,6-dimethyltyrosine 
• 480446-85-3 (2-{[((S)-1,2,3,4-Tetrahydro-isoquinoline-3-carbonyl)-amino]-methyl}-benzoimidazol-1-yl)-acetic acid ethyl ester 

Downstream Products

• 873530-30-4 [2-{3-[(1-carbamoylmethyl-1H-benzoimidazol-2-ylmethyl)-carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl}-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 873530-29-1 {2-[({(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-methyl]-benzoimidazol-1-yl}-acetic acid 

Relevant academic research and scientific papers

Conversion of the potent δ-opioid agonist H-Dmt-Tic-NH-CH 2-Bid into δ-opioid antagonists by N1-benzimidazole alkylation

N1-Alkylation of 1H-benzimidizole of the δ agonist H-Dmt-Tic-NH-CH2-Bid with hydrophobic, aromatic, olefinic, acid, ethyl ester, or amide (1-6) became δ antagonists (pA2 = 8.52-10.14). δ- and μ-Opioid receptor affinities w

Potent δ-opioid receptor agonists containing the Dmt-Tic pharmacophore

Conversion of δ-opioid receptor antagonists containing the 2′,6′-dimethyl-L-tyrosine (Dmt)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) pharmacophore into potent δ-agonists required a third heteroaromatic nucleus, such as 1H-benzimidazole-2-yl (