480464-65-1Relevant articles and documents
BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS
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Page/Page column 30, (2010/02/12)
Compounds of Formula: (I); wherein: R1 is selected from: fluoro, chloro, C1-3alkyl and C1-3alkoxy; R2-X- is selected from: methyl, methoxymethyl and Formula: (X); n is 0,1 or 2; or a salt, pro-drug or solvate thereof are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.
BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS
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Page/Page column 28-29, (2008/06/13)
A compound of Formula (I): Formula (I) wherein: R1 is selected from hydrogen and C1-4alkyl; R2 is selected from: R4-C(R5aR5b)- , R4=C(R6)- and R7aC(R7b
Discovery, synthesis and biological evaluation of novel glucokinase activators
McKerrecher, Darren,Allen, Joanne V.,Bowker, Suzanne S.,Boyd, Scott,Caulkett, Peter W. R.,Currie, Gordon S.,Davies, Christopher D.,Fenwick, Mark L.,Gaskin, Harold,Grange, Emma,Hargreaves, Rod B.,Hayter, Barry R.,James, Roger,Johnson, Keith M.,Johnstone, Craig,Jones, Clifford D.,Lackie, Sarah,Rayner, John W.,Walker, Rolf P.
, p. 2103 - 2106 (2007/10/03)
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharmacoki
