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4807-99-2

All-trans-13-demethylretinol, also known as 13-demethylretinol or vitamin A2, is a naturally occurring form of vitamin A that is structurally similar to the more common all-trans-retinol (vitamin A1). It is primarily found in certain fish species, such as trout and salmon, and in the liver of some animals. all-trans-13-demethylretinol plays a crucial role in maintaining healthy vision, immune function, and cell growth. All-trans-13-demethylretinol is synthesized in the body from beta-carotene, a precursor found in various fruits and vegetables, and it exhibits similar biological activities to retinol, although it is less potent. The presence of this vitamin A derivative in certain foods contributes to the overall vitamin A content and can be beneficial for maintaining optimal health.

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  • 4807-99-2 Structure

  • Basic information

    1. Product Name: all-trans-13-demethylretinol
    2. Synonyms: all-trans-13-demethylretinol
    3. CAS NO:4807-99-2
    4. Molecular Formula:
    5. Molecular Weight: 272.431
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4807-99-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: all-trans-13-demethylretinol(CAS DataBase Reference)
    10. NIST Chemistry Reference: all-trans-13-demethylretinol(4807-99-2)
    11. EPA Substance Registry System: all-trans-13-demethylretinol(4807-99-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4807-99-2(Hazardous Substances Data)

4807-99-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4807-99-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,0 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4807-99:
(6*4)+(5*8)+(4*0)+(3*7)+(2*9)+(1*9)=112
112 % 10 = 2
So 4807-99-2 is a valid CAS Registry Number.

4807-99-2Relevant articles and documents

Synthesis of C11-to-C14 methyl-shifted all-: Trans -retinal analogues and their activities on human aldo-keto reductases

Alvarez, Rosana,Barracco, Vito,De Lera, Angel R.,Domínguez, Marta,Farrés, Jaume,Jiménez, Rafael,López, Susana,Parés, Xavier,Pequerul, Raquel,Rivas, Aurea

, p. 4788 - 4801 (2020/07/13)

Human aldo-keto reductases (AKRs) are enzymes involved in the reduction, among other substrates, of all-trans-retinal to all-trans-retinol (vitamin A), thus contributing to the control of the levels of retinoids in organisms. Structure-activity relationship studies of a series of C11-to-C14 methyl-shifted (relative to natural C13-methyl) all-trans-retinal analogues as putative substrates of AKRs have been reported. The synthesis of these retinoids was based on the formation of a C10-C11 single bond of the pentaene skeleton starting from a trienyl iodide and the corresponding dienylstannanes and dienylsilanes, using the Stille-Kosugi-Migita and Hiyama-Denmark cross-coupling reactions, respectively. Since these reagents differ by the location and presence of methyl groups at the dienylorganometallic fragment, the study also provided insights into the ability of the different positional isomers to undergo cross-coupling and the sensitivity of these processes to steric hindrance. The resulting C11-to-C14 methyl-shifted all-trans-retinal analogues were found to be active substrates when tested with AKR1B1 and AKR1B10 enzymes, although relevant differences in substrate specificities were noted. For AKR1B1, all analogues exhibited higher catalytic efficiency (kcat/Km) than parent all-trans-retinal. In addition, only all-trans-11-methylretinal, the most hydrophobic derivative, showed a higher value of kcat/Km = 106 000 ± 23 200 mM-1 min-1 for AKR1B10, which is in fact the highest value from all known retinoid substrates of this enzyme. The novel structures, identified as efficient AKR substrates, may serve in the design of selective inhibitors with potential pharmacological interest. This journal is

The Suzuki Reaction in Stereocontrolled Polyene Synthesis: Retinol (Vitamin A), its 9- and/or 13-Demethyl Analogs, and Related 9-Demethyl-dihydroretinoids

Torrado, Alicia,Iglesias, Beatriz,Lopez, Susana,Lera, Angel R. de

, p. 2435 - 2454 (2007/10/02)

A new synthesis of retinol (vitamin A) and 9- and/or 13-demethylretinols, with essentially complete control of regio- and stereochemistry, is described which is based on the thallium-accelerated, palladium-catalyzed cross-coupling reactions of (E)-1-alkenylboronic acids and (E)-1-alkenyl iodides (Suzuki reaction).The procedure has also been extended to the stereocontrolled synthesis of a series of 9-demethyl-dihydroretinoids of potential biological interest.

On the photoisomerisation of 13-desmethyl-retinal

Gaertner, Wolfgang,Hopf, Henning,Hull, William E.,Oesterhelt, Dieter,Scheutzow, Dieter,Towner, Paul

, p. 347 - 350 (2007/10/02)

All mono-cis-isomers of 13-desmethyl-retinal have been prepared fro the alll-trans-compound by photoisomerisation. The various isomers were separated by HPLC and identified by their 400 MHz-1NMR-spectra.

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