48071-45-0Relevant academic research and scientific papers
Interaction of plasma proteins with tri-quaternary ammonium salt cationic surfactant studied by QCM-D
Xi, Man,Zhang, Baoyan
, p. 253 - 260 (2015)
A tri-quaternary ammonium salt cationic surfactant was synthesized. Its structure was confirmed by using Fourier- transform infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, and X-ray photoelectron spectroscopy analyses. Three model surfaces, including Au-CH3, Au-OH and Au-COOH, were fabricated. Adsorptions of surfactant on the three model surfaces and subsequent plasma proteins adsorption were investigated by quartz crystal microbalance with dissipation (QCM-D). The mass of surfactant on the Au-COOH surface was the largest, followed by that on the Au-CH3 surface, and that on the Au-OH surface. These results suggested that the main driving force of surfactant immobilization was electrostatic interaction followed by hydrophobic interaction. Based on the results obtained, we concluded that the protein mass adsorbed on Au-CH3-S, Au-OH-S, and Au-COOH-S surfaces depended on the protein size and orientation. The mass and thickness of S on the Au-COOH surface is the largest and the protein adsorption capacity of Au-COOH-S surface is inferior to that of Au-CH3-S. The Au-COOH-S surface could inhibit lysozyme adsorption, maintain the adsorption balance of bovine serum albumin, and induce fibrinogen-binding protein adsorption.
Rational design, synthesis and evaluation of new azido-ester structures as green energetic plasticizers
Fareghi-Alamdari, Reza,Sheibani, Nasser,Zohari, Narges
supporting information, p. 12695 - 12706 (2020/10/02)
Computer-aided molecular design (CAMD) is a well-known tool for the theoretical assessment of chemical structures before their experimental synthesis. In this study, we used this method to consider the important criteria for a chemical structure as an energetic plasticizer for an energetic azido binder. The number of new azido-ester structures were initially designed, and their physicochemical and energetic properties were determinedviatheoretical calculation by molecular dynamics simulations and machine learning-based methods. Considering the balances between several criteria, two of these theoretical chemical structures (including GTAA (glyceryl tris(azidoacetate)) and TEGBAA (triethyleneglycol bis(azidoacetate))) were then selected, synthesized, and characterized. The comparison of experimental and theoretical results to evaluate the physicochemical properties of these new azido-ester plasticizers showed an acceptable agreement between the two methods. Finally, the compatibility and efficiency of these two new azido-ester plasticizers on the rheological and thermal properties of glycidyl azide polymer (GAP) were investigated using rheometry and DSC analyses, and compared with some common energetic plasticizers. The results confirmed that these two new azido-esters are appropriate plasticizers for GAP since they exhibited higher safety over comparable plasticizers, in addition to the real performance.
Processes for the Preparation of Lesinurad and Intermediates Thereof
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Paragraph 0202-0203, (2018/10/04)
The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS
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Page/Page column 34, (2012/08/08)
The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.
HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS
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, (2009/04/24)
The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.
BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF
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, (2009/12/05)
Novel bioabsorbable and/or biocompatible polyurethanes, polyureas, polyamideurethanes and polyureaurethanes with tunable physical, mechanical properties and hydrolytic degradation profiles are provided for use in biomedical applications such as stents, stent coatings, scaffolds, foams, and films. The disclosed polymers may be derived from biocompatible and/or bioabsorbable polyisocyanates. The present invention also relates to new and improved methods for the preparation of the biocompatible and/or bioabsorbable polyisocyanates.
