480997-16-8Relevant academic research and scientific papers
Hydrolase-catalysed preparation of chiral a,a-disubstituted cyanohydrin acetates
Holt, Jarle,Arends, Isabel W. C. E.,Minnaard, Adriaan J.,Hanefeld, Uif
, p. 1341 - 1344 (2007)
The enzymatic hydrolysis of esters of tertiary alcohols has long been a challenge. In particular their kinetic resolutions have virtually not been addressed. Here we describe the successful kinetic resolution of a,a-disubstituted cyanohydrin acetates, a t
Microbial-catalysed resolution of sterically demanding cyanohydrins
Paravidino, Monica,Holt, Jarle,Romano, Diego,Singh, Neetu,Arends, Isabel W.C.E.,Minnaard, Adriaan J.,Orru, Romano V.A.,Molinari, Francesco,Hanefeld, Ulf
experimental part, p. 87 - 92 (2010/11/02)
Mycelia containing carboxyl-esterases, a novel source of enzymes, have been investigated in the hydrolytic kinetic resolution of one type of tert-alcohols, α,α-disubstituted cyanohydrins. This class of enzymes was found to be both active and selective towards these tert-alcohols, giving E-values as high as 42.
