29624-91-7

Upstream product

• 143-33-9 sodium cyanide 
• 98-86-2 acetophenone 
• 20102-12-9 2-hydroxy-2-phenylpropionitrile 
• 108-24-7 acetic anhydride 
• 127462-20-8 2-phenyl-2-trimethylsilyloxypropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 495-10-3 2-phenylacrylonitrile 
• 480997-16-8 C₁₁H₁₁NO₂ 
• 169221-14-1 (R)-(+)-2-hydroxy-2-phenylpropanenitrile 
• 174849-24-2 (S)-2-(hydroxy)-2-phenyl-propanonitrile 
• 98-86-2 acetophenone 
• 99563-95-8 4-amino-5-methyl-5-phenyl-2(5H)-furanone 

Relevant academic research and scientific papers

An efficient and facile one-pot synthesis of cyanohydrin esters from carbonyl compounds catalyzed by iron(III) chloride

A variety of cyanohydrin esters were readily prepared from carbonyl compounds with trimethylsilyl cyanide and acid anhydride under the influence of a catalytic amount of iron(III) chloride in a convenient one-pot procedure.

A one-pot esterification of chiral O-trimethylsilyl-cyanohydrins with retention of stereochemistry

Enantiomerically enriched O-TMS cyanohydrins have been transformed directly into O-acyl-cyanohydrins using various anhydrides or acid chlorides in the presence of catalytic amounts of scandium(III) triflate. The reaction occurs with full retention of ster

KINETIC RESOLUTION OF KETONE CYANOHYDRIN ACETATES WITH A MICROBIAL ENZYME

Incubation of dl-1-cyano-1-metylalkyl (or alkenyl) acatates (methyl ketone cyanohydrin acetates) with cells of Pichia miso IAM 4682 afforded optically active acetates and the corresponding ketones via asymmetric hydrolysis.Resulting (S)-2-cyano-2-undecyl acetate was converted to the aminofuranone derivative without losing its optical purity.

NEW SYNTHETIC METHODS FOR 4-AMINO-2(5H)-FURANONES

Two new efficient methods are disclosed for the synthesis of the title compounds: (1) base-promoted ring closure of 2-acyloxy alkanenitrile and (2) acid-mediated lactonization of t-butyl-4-alkoxy-3-amino-2-alkenoates.