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481-05-0

ARTEMISIN, also known as qinghaosu, is a chemical compound derived from the sweet wormwood plant (Artemisia annua). It possesses potent anti-malarial properties and has been widely used in the treatment of drug-resistant strains of malaria. ARTEMISIN works by targeting the malaria parasite and disrupting its ability to reproduce within the body, ultimately leading to the destruction of the parasite. Furthermore, ARTEMISIN has demonstrated potential in the treatment of other diseases, such as cancer, due to its ability to induce cell death in cancer cells. Its therapeutic benefits and impact on global health have garnered significant attention and research.

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  • Naphtho[1,2-b]furan-2,8(3H,4H)-dione,3a,5,5a,9b-tetrahydro-4-hydroxy-3,5a,9-trimethyl-, (3S,3aR,4S,5aS,9bS)-

    Cas No: 481-05-0

  • USD $ 1.9-2.9 / Gram

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  • 481-05-0 Structure

  • Basic information

    1. Product Name: ARTEMISIN
    2. Synonyms: 3a,5,5a,9b-tetrahydro-4-hydroxy-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8-dione;ARTEMISIN (COTEXIN);(3S)-3aβ,5,5a,9bα-Tetrahydro-4β-hydroxy-3,5aα,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)-dione;(3S)-3β,5aα,9-Trimethyl-4β-hydroxy-2,3,3aβ,4,5,5a,8,9bα-octahydronaphtho[1,2-b]furan-2,8-dione;4β-Hydroxy-3β,5aα,9-trimethyl-3,3aβ,4,5,5a,9bα-hexahydronaphtho[1,2-b]furan-2,8-dione;Artemisin;(3S,3aR,4S,5aS,9bS)-4-hydroxy-3,5a,9-trimethyl-3a,4,5,9b-tetrahydro-3H-benzo[g][1]benzofuran-2,8-dione;(3S,3aR,4S,5aS,9bS)-4-hydroxy-3,5a,9-trimethyl-3a,4,5,9b-tetrahydro-3H-benzo[g]benzofuran-2,8-quinone
    3. CAS NO:481-05-0
    4. Molecular Formula: C15H18O4
    5. Molecular Weight: 262.30102
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 481-05-0.mol

  • Chemical Properties

    1. Melting Point: 203°
    2. Boiling Point: bp0.1 260°
    3. Flash Point: 178.8°C
    4. Appearance: /
    5. Density: 1.26g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.81±0.70(Predicted)
    10. CAS DataBase Reference: ARTEMISIN(CAS DataBase Reference)
    11. NIST Chemistry Reference: ARTEMISIN(481-05-0)
    12. EPA Substance Registry System: ARTEMISIN(481-05-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. RIDADR: 2811
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 6.1(a)
    8. PackingGroup: II
    9. Hazardous Substances Data: 481-05-0(Hazardous Substances Data)

481-05-0 Usage

Uses

Used in Pharmaceutical Industry:
ARTEMISIN is used as an anti-malarial drug for the treatment of drug-resistant strains of malaria. It targets the malaria parasite and disrupts its ability to reproduce within the body, leading to the destruction of the parasite.
Used in Oncology:
ARTEMISIN is used as a potential cancer treatment due to its ability to induce cell death in cancer cells. Its potential therapeutic benefits in oncology are currently under investigation and have garnered significant research interest.

Check Digit Verification of cas no

The CAS Registry Mumber 481-05-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 481-05:
(5*4)+(4*8)+(3*1)+(2*0)+(1*5)=60
60 % 10 = 0
So 481-05-0 is a valid CAS Registry Number.
InChI:InChI=1S/C15H18O4/c1-7-9(16)4-5-15(3)6-10(17)11-8(2)14(18)19-13(11)12(7)15/h4-5,8,10-11,13,17H,6H2,1-3H3/t8-,10-,11+,13-,15+/m0/s1

481-05-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,3aR,4S,5aS,9bS)-4-hydroxy-3,5a,9-trimethyl-3a,4,5,9b-tetrahydro-3H-benzo[g][1]benzofuran-2,8-dione

1.2 Other means of identification

Product number -
Other names Naphtho(1,2-b)furan-2,8(3H,4H)-dione,3a,5,5a,9b-tetrahydro-4-hydroxy-3,5a,9-trimethyl-,(3S-(3alpha,3aalpha,4alpha,5abeta,9bbeta))

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:481-05-0 SDS

481-05-0Upstream product

481-05-0Relevant articles and documents

Biotransformation of 6α-santonin and 1,2-dihydro-α-santonin by Acremonium chrysogenum PTCC 5271 and Rhizomucor pusillus PTCC 5134

Gandomkar, Somayyeh,Habibi, Zohreh

, p. 59 - 63 (2015/01/08)

Biotransformation of 6α-santonin (1) and 1,2-dihyro-α-santonin (2) by two fungal strains Acremoniumchrysogenum (Cephalosporium chrysogenum) and Rhizomucor pusillus has been investigated for the firsttime. After 8 days of incubation of 1 by A. chrysogenum, four known metabolites including 1,2-dihydro-α-santonin (2) (30%), 8α-hydroxyl-α-santonin (3) (22%), 15-hydroxy-α-santonin (4) (15%) and 4,5-dihydro-α-santonin (5) (10%) were obtained. Incubation of 1 by R. pusillus afforded two metabolites 2 (45%) and 3(20%). Biotransformation of 1,2-dihyro-α-santonin by A. chrysogenum produced tetrahydro-α-santonin(6) with 52% yield and tetrahydroartemisin (7) with 33% yield. By R. pusillus, the yields of 6 and 7 were32% and 21%, respectively. The structures of the products were identified on the basis of spectroscopic data.

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