481-20-9Relevant articles and documents
Hydropyrolysis over a platinum catalyst as a preparative technique for the compound-specific carbon isotope ratio measurement of C27 steroids
Meredith, Will,Gomes, Rachel L.,Cooper, Mick,Snape, Colin E.,Sephton, Mark A.
, p. 501 - 505 (2010)
Compound-specific stable carbon isotope analysis by gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS) is an important method for the determination of the 13C/12C ratios of biomolecules such as steroids, for a wide range of applications. However, steroids in their natural form exhibit poor chromatographic resolution, while derivatisation adds carbon thereby corrupting the stable isotopic composition. Hydropyrolysis with a sulphided molybdenum catalyst has been shown to defunctionalise the steroids, while leaving their carbon skeleton intact, allowing for the accurate measurement of carbon isotope ratios. The presence of double bonds in unsaturated steroids such as cholesterol resulted in significant rearrangement of the products, but replacing the original catalyst system with one of platinum results in higher conversions and far greater selectivity. The improved chromatographic performance of the products should allow GC/C/IRMS to be applied to more structurally complex steroid hormones and their metabolites.
Action of lithium ethylenediamine on 1,4-diketone
Ghosh, Pranab,Chakraborty, Prasanta
experimental part, p. 1125 - 1128 (2011/06/19)
Reactions of lithium ethylenediamine (Li/EDA) have been carried out on 1,4-diketones such as cholest-4(5)-en-3,6-dione (1) and hexane-2,5-dione (7). The resulting compounds have been characterized by optical rotation, IR, mass spectra and by comparison with authentic samples.
Safe, facile radical-based reduction and hydrosilylation reactions in a microreactor using tris(trimethylsilyl)silane
Odedra, Arjan,Geyer, Karolin,Gustafsson, Tomas,Gilmour, Ryan,Seeberger, Peter H.
scheme or table, p. 3025 - 3027 (2009/02/04)
A highly efficient system for tris(trimethylsilyl)silane (TTMSS) mediated deoxygenation, dehalogenation and hydrosilylation reactions is described in a microstructured device; this convenient platform enables the scale up of radical-based processes. The Royal Society of Chemistry.
