481052-22-6Relevant articles and documents
Carbohydrate-carbohydrate recognition between Lewis X blood group antigens, mediated by calcium ions
Gege, Christian,Geyer, Armin,Schmidt, Richard R.
, p. 2475 - 2485 (2007/10/03)
Bivalent Lewis X (LeX) oligosaccharides were synthesised in order to study the conformational details of carbohydrate clusters by NMR spectroscopy. To this end, two Lex trisaccharide moieties (1) were covalently linked through the 6-hydroxy group or through the anomeric oxygen of GlcNAc to yield dimers 2 and 3, respectively. The two Lex halves of the model saccharide 2 exhibited cooperativity in calcium binding. Three different lactosides served as control compounds for NMR titration with calcium chloride. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.