481075-14-3Relevant academic research and scientific papers
Isomerization of chiral non-racemic α-substituted propargylic amines to terminal acetylenes
Blanchet, Jerome,Bonin, Martine,Micouin, Laurent,Husson, Henri-Philippe
, p. 2598 - 2602 (2002)
Various α-substituted propargylamines, prepared in three steps from (R)-phenylglycinol, are readily isomerized at 0 °C with KAPA to form terminal acetylenic amines, without any detectable epimerization of the chiral center, as already observed for propargyl alcohols. Enantiomerically pure primary α-substituted alkynylamines can be easily obtained in two steps after removal of the ferrocenylmethyl protective group and oxidative cleavage of the chiral appendage, Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
