481075-38-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-5-hydroxymethyl-benzoic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with specific therapeutic properties, enhancing the range of available treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-5-hydroxymethyl-benzoic acid is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these products can lead to enhanced efficacy and selectivity in controlling pests and weeds.
Used in Dye and Pigment Production:
2-Fluoro-5-hydroxymethyl-benzoic acid is used as a key component in the manufacturing of dyes and pigments. Its chemical properties enable the production of a wide array of colors and shades, catering to various applications in industries such as textiles, plastics, and printing inks.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-Fluoro-5-hydroxymethyl-benzoic acid is employed for the creation of complex organic molecules. Its presence in these molecules can impart specific chemical and physical properties, broadening the scope of chemical research and development.
Used in Material Science:
2-Fluoro-5-hydroxymethyl-benzoic acid has potential applications in the development of new materials, such as polymers and composites. Its unique structure can contribute to the enhancement of material properties, leading to innovative solutions in various fields.
Used in Academic Research:
In the realm of academic research, 2-Fluoro-5-hydroxymethyl-benzoic acid serves as a valuable compound for studying chemical reactions and exploring new synthetic pathways. Its versatility and potential applications make it an essential tool for advancing scientific knowledge.

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 124-38-9 carbon dioxide 
• 227609-85-0 2-fluoro-5-(hydroxymethyl)benzonitrile 
• 709-45-5 2-fluoro-5-bromomethyl benzoic acid methyl ester 
• 104620-55-5 1-fluoro-4-[(methoxymethoxy)methyl]benzene 

Downstream Products

• 816449-70-4 methyl 2-fluoro-5-(hydroxymethyl)benzoate 
• 891833-15-1 4-(2-Fluoro-5-hydroxymethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

PARP inhibitors

A compound of the formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R2, R3, R4 and R5 are independently selected from the group consisting of H, C1-7 /su

TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxicity to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the invention also decrease the volume and weight of a tumor and have a strong angiogenesis inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the present invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor.

Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization

It was possible to functionalize the three fluorobenzyl alcohols and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an O-protective group making seven new fluorobenzoic acids accessible in 63% average yield. Moreover, the TIPS group tolerates weakly basic and acidic media and, therefore, may facilitate further structural elaboration. The unprotected alcohols reacted more sluggishly and were unable to provide two of the targeted products (acids 1 and 2). The yield averaged only 46% in the five other cases (acids 3-7). The direct metalation of fluorinated benzyl and phenethyl alcohols remains nevertheless an attractive option because of its operational simplicity. All three (trifluoromethyl)benzyl alcohols and two of the three (trifluoromethyl)phenethyl alcohol isomers were successfully submitted to the metalation/functionalization sequence. These five starting materials gave rise to a total of nine new benzoic acids or lactones (compounds 8-14 and 17-18). Despite the poor yields (31% on average), the organometallic methods employed are, in general, extremely selective, economical and easy to perform. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.