4815-31-0Relevant academic research and scientific papers
Microwave-assisted synthesis of 2-amino-thiophene-3-carboxylic derivatives under solvent-free conditions
Huang, Wei,Li, Jian,Tang, Jing,Liu, Hong,Shen, Jianhua,Jiang, Hualiang
, p. 1351 - 1357 (2007/10/03)
Under microwave irradiation and solvent-free conditions, cyanoacetates (cyanoacetamides) react with ketones and sulphur in the presence of a small amount of morpholine to give 2-amino-thiophene-3-carboxylic derivatives. In particular, tetrahydro-benzo[b]thiophene-3-carboxylic acid N-aryl amides were synthesized in high yields of 84-95%. Copyright Taylor & Francis, Inc.
