481634-76-8Relevant academic research and scientific papers
Small-Molecule Absorber A1094 as a Stable and Fast-Clearing NIR-II Imaging Agent
Huang, Yanfang,Liu, Huanhuan,Chen, Xueyuan,Zhang, Yunming,Zhao, Xingyang,Huang, Wenchao,Mou, Zhaobiao,Wang, Chao,Zhang, Kaiqiang,Li, Zijing
, p. 2497 - 2503 (2021)
Photoacoustic imaging (PAI) in the second near-infrared window (NIR-II) is conducive to deep-tissue imaging due to small scattering coefficients, but often requires exogenous imaging agents. At present, nanoparticle-based NIR-II imaging agents are mainly used in non-clinical studies, some basic components of which are resistant to metabolism in vivo. The aim of this study was to examine the ～600 Da croconaine absorber A1094, absorbing lights around 1094 nm, as a rare, small-molecule NIR-II imaging agent in vivo. The clinical translational potential of A1094 injection were systematically revealed, including sufficient solubility and freeness in blood, good anti-interference ability, and favourable pH/oxidation-reduction/metabolic stabilities. After intravenous administration of A1094 injection, PAI of murine ears exhibited comparable capillaries visibility to that of PAI with popular Au nanorods. The contrasts achieved with A1094 and Au nanorods were 1.78 and 1.29 times higher than before administration, in the healthy group, and 3.25 and 1.58 times higher in the inflammation group. Notably, A1094 demonstrated a desired faster liver clearance than Au nanorods. The PAI signal of A1094 was cleared by 74.2 % after 3 h, whereas Au nanorods were only cleared by 43.1 %. The main metabolic mechanisms of A1094 were identified as N-methylation and lipid hydrolysis by murine liver microsomes in vitro. Therefore, A1094 may have promising clinical potential as a stable and fast-clearing NIR-II imaging agent.
Tumor Microenvironment-Activated NIR-II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis
Chen, Guangcun,Li, Chunyan,Ling, Sisi,Wang, Qiangbin,Yang, Hongchao,Yang, Xiaohu,Zhang, Yejun
, p. 7219 - 7223 (2020)
Activatable theranostic systems show potential for improved tumor diagnosis and therapy owing to high detection specificities, effective ablation, and minimal side-effects. Herein, a tumor microenvironment (TME)-activated NIR-II nanotheranostic system (FEAD1) for precise diagnosis and treatment of peritoneal metastases is presented. FEAD1 was fabricated by self-assembling the peptide Fmoc-His, mercaptopropionic-functionalized Ag2S quantum dots (MPA-Ag2S QDs), the chemodrug doxorubicin (DOX), and NIR absorber A1094 into nanoparticles. We show that in healthy tissue, FEAD1 exists in an NIR-II fluorescence “off” state, because of Ag2S QDs-A1094 interactions, while DOX remains in stealth mode. Upon delivery of FEAD1 to the tumor, the acidic TME triggers its disassembly through breakage of the Fmoc-His metal coordination and DOX hydrophobic interactions. Release of A1094 switches on Ag2S fluorescence, illuminating the tumor, accompanied by burst release of DOX within the tumor tissue, thereby achieving precise tumor theranostics. This TME-activated theranostic strategy holds great promise for future clinical applications.
An Activatable NIR-II Nanoprobe for In Vivo Early Real-Time Diagnosis of Traumatic Brain Injury
Li, Chunyan,Li, Wanfei,Liu, Huanhuan,Zhang, Yejun,Chen, Guangcun,Li, Zijing,Wang, Qiangbin
, p. 247 - 252 (2020)
Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis and real-time feedback on the pathological process. Herein, a targeted activ
Photoelectrical Stimulation of Neuronal Cells by an Organic Semiconductor-Electrolyte Interface
Abdullaeva, Oliya S.,Schulz, Matthias,Balzer, Frank,Parisi, Jürgen,Lützen, Arne,Dedek, Karin,Schiek, Manuela
, p. 8533 - 8542 (2016)
As a step toward the realization of neuroprosthetics for vision restoration, we follow an electrophysiological patch-clamp approach to study the fundamental photoelectrical stimulation mechanism of neuronal model cells by an organic semiconductor-electrolyte interface. Our photoactive layer consisting of an anilino-squaraine donor blended with a fullerene acceptor is supporting the growth of the neuronal model cell line (N2A cells) without an adhesion layer on it and is not impairing cell viability. The transient photocurrent signal upon illumination from the semiconductor-electrolyte layer is able to trigger a passive response of the neuronal cells under physiological conditions via a capacitive coupling mechanism. We study the dynamics of the capacitive transmembrane currents by patch-clamp recordings and compare them to the dynamics of the photocurrent signal and its spectral responsivity. Furthermore, we characterize the morphology of the semiconductor-electrolyte interface by atomic force microscopy and study the stability of the interface in dark and under illuminated conditions.
Electro-optical Properties of Neutral and Radical Ion Thienosquaraines
Maltese, Vito,Cospito, Sante,Beneduci, Amerigo,De Simone, Bruna Clara,Russo, Nino,Chidichimo, Giuseppe,Janssen, René A. J.
supporting information, p. 10179 - 10186 (2016/07/19)
Thienosquaraines are an interesting class of electroactive dyes that are useful for applications in organic electronics. Herein, the redox chemistry and electrochromic response of a few newly synthesized thienosquaraines are presented. These properties are compared to those of the commercial 2,4-bis[4-(N,N-diisobutylamino)-2,6-dihydroxyphenyl]squaraine. The stability of the radical ions formed in electrochemical processes strongly affects these properties, as shown by cyclic voltammetry, in situ spectroelectrochemistry, and quantum chemical calculations. Furthermore, all of the dyes show aggregation tendency resulting in panchromatic absorption covering the whole UV/Vis spectral range.
A series of asymmetric squaraine cyanine small molecule and its preparation method and application
-
Paragraph 0056; 0057, (2016/10/07)
The invention discloses a series of asymmetrical squarine micromolecules as well as a preparation method and an application thereof. Donor-receptor-donor type asymmetrical squarine micromolecules are formed by adopting two different electron-rich aromatic units as donors and leading 1,3-squaric acid cells with high electronic affinity into a conjugated system as receptors, so that micromolecule materials with low band gaps are acquired, and the absorption spectrum of the micromolecule materials can cover visual and near-infrared regions by 450-800nm; and meanwhile, the compounds prepared through the preparation method are good in dissolubility and film-forming property, which is very favorable for preparing organic solar cells with good performance.
Search for squaraine derivatives that can be sublimed without thermal decomposition
Tian, Minquan,Furuki, Makoto,Iwasa, Izumi,Sato, Yasuhiro,Pu, Lyong Sun,Tatsuura, Satoshi
, p. 4370 - 4376 (2007/10/03)
To search for sublimable squaraine (SQ) dyes for fabricating thin films under vacuum, we have synthesized a series of 2,4-bis[4-(N,N-dialkylamino)-2,6-dihydroxyphenyl]squaraines [SQ(OH)4] and studied their properties. The investigation of the b
