481648-74-2Relevant academic research and scientific papers
Synthesis and spectral studies of 2-substituted-4,5-dihydronaphtho[1,2-c]pyrazole derivatives of pharmacological interest
Faidallah, H. M.,Basaif, S. A.,Sharshira, E. M.,A-Ba-Oum, A.
, p. 905 - 914 (2007/10/03)
A series of pyrazole derivatives 3a-d, 4b-d and 5b-d were prepared. Condensation of the diketoester 2 with monosubstituted hydrazines afforded 2-substituted 3-ethoxycarbonyl-4,5-dihydronaphtho[1,2-c]pyrazoles 3a-d in good yields. Treatment of pyrazoles 3b-d with hydrazines gave the corresponding hydrazides 4b-d. When the acid hydrazides 4b-d, were reacted with phenyl isothiocyanates they gave the corresponding thiosemicarbazides 5b-d. Cyclodehydration of 5c,d with sulfuric acid gave the corresponding thiadiazolyl derivatives 6c,d. The structures of the isolated compounds were fully determined by spectral methods.
Synthesis and spectral characterization of novel 1,3,4-oxadiazole and 1,2,4-triazole derivatives: Synthesis for potential pharmacological activities
Faidallah, Hassan M.,Sharshira, Essam M.,Basaif, Salem A.,A-Ba-Oum, Abd El-Kader
, p. 67 - 79 (2007/10/03)
Oxadiazole derivatives (3a,b) and (4a,b) were obtained in a good yield by the reaction of the benzylidene derivatives (2a,b) with acetic anhydride and yellow mercuric oxide respectively. Cyclodesulfurization of the thiosemicarbazide derivatives (5a-c) with yellow mercuric oxide afforded the oxadiazoles (7a-c). On the other hand, reaction of (5a-c) with sodium hydroxide gave the triazoles (6a-c). The structures of the isolated products were fully determined by spectral methods.
