481648-58-2Relevant academic research and scientific papers
Synthesis and spectral studies of 2-substituted-4,5-dihydronaphtho[1,2-c]pyrazole derivatives of pharmacological interest
Faidallah, H. M.,Basaif, S. A.,Sharshira, E. M.,A-Ba-Oum, A.
, p. 905 - 914 (2007/10/03)
A series of pyrazole derivatives 3a-d, 4b-d and 5b-d were prepared. Condensation of the diketoester 2 with monosubstituted hydrazines afforded 2-substituted 3-ethoxycarbonyl-4,5-dihydronaphtho[1,2-c]pyrazoles 3a-d in good yields. Treatment of pyrazoles 3b-d with hydrazines gave the corresponding hydrazides 4b-d. When the acid hydrazides 4b-d, were reacted with phenyl isothiocyanates they gave the corresponding thiosemicarbazides 5b-d. Cyclodehydration of 5c,d with sulfuric acid gave the corresponding thiadiazolyl derivatives 6c,d. The structures of the isolated compounds were fully determined by spectral methods.
